HC70A_W13 Course Document

Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2013

Professor Bob Goldberg

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Course Documents


Course Info:
	Units:	5.0
	Lectures:	Tues & Thurs : 3:30 - 6:00 PM
	Location:	La Kretz 120
	Discussions:	Wed : 1:00 - 2:50 PM Eden Maloney (La Kretz 100) Wed : 3:00 - 4:50 PM Reece Fenning (La Kretz 100) Wed : 5:00 - 6:50 PM Mike Lyons (La Kretz 100)
	Office Hours:	Mon: 10:00AM - 12:00PM Eden Maloney (Hershey Hall 318) Tues: 10:00AM - 12:00PM Mike Lyons (Hershey Hall 318) Thur: 12:30PM - 2:30PM Reece Fenning (Hershey Hall 318) Fri: 1:00PM - 2:00PM Dr. Bob Goldberg (Terasaki Life Sci 4121)

Class Video		Watch Movie
Class Syllabus		Download File

Class Handouts and Powerpoint Presentation
Week 1
	01/08/13 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One) 01/10/13 - Film: Gene Egineers: Playing God

Week 2
	01/15/13 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two) 01/17/13 - Film: Race for the Double Helix

Week 3
	01/22/13 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One) 01/24/13 - Guest Speaker Handout (pdf): Engineering Crops For the Developing World by Dr. Prakash Crop Genetic Engineering - What's All the Fuss About? by Dr. McHughen

Week 4
	01/29/13 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two) 01/31/13 - Film: Conviction

Week 5
	02/05/13 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Hemophilia Story 02/07/13 - Guest Speaker Handout (pdf): Catching Criminals With DNA: It's Not CSI by Criminologist Harry Kalnn

Week 6
	02/12/13 - All-Class Midterm Oral Exam 02/14/13 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications

Week 7
	02/19/13 - Lecture Seven Handout (pdf): Your Personal Genome & Tracing Your Ancenstry 02/21/13 - Guest Speaker Handout (pdf): Stem Cell Biology and Ethics by Dr. Pei Yun Lee

Week 8
	02/26/13 - Lecture Eight Handout (pdf) by Dr. John Harada: Human Genetic Engineering & Gene Therapy 02/28/13 - Film: Extraordinary Measures

Week 9
	03/05/13 - Guest Speaker Handout (pdf): In Vitro Fertilization & Genetic Testing by Dr. Michele Evans 03/07/2013 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & Genetic Engineering
Week 10
	03/12/13 - Lecture Ten Handout (pdf): Science and the Constitution: Who Owns Your Genes? 03/14/13 - Final All-Class Oral Exam

Guest Speakers (Click on the name for information about the speaker)
	Dr. Channapatna Prakash, Ph.D. Professor in Plant Molecular Genetics, Tuskegee University Title: Engineering Crops for the Developing World
	Dr. Alan McHughen, Ph.D. CE Plant Biotechnologist, Department of Plant Sciences, UC Riverside Title: Crop Genetic Engineering - What's All the Fuss About?
	Harry Klann Supervising Criminologist, DNA Unit, LAPD Title: Catching Criminals With DNA: It's Not CSI
	Dr. PeiYun Lee, Ph.D. UCLA Department of Molecular, Cell, and Developmental Biology Title: Stem Cells - Promise, Reality, and Conflict
	Dr. Michele Evans, M.D., FACOG Reproductive Specialist, Pacific Fertility Center Los Angeles Title: In Vitro Fertilization & Genetic Testing

Articles For Discussion
	Discussion One: Genetic Engineering Then & Now (click here to download the articles)
		1. Doomsday:Tinkering With Life, Time Magzine April 18, 1977.
		2. The Miracles of Spliced Genes, Newsweek Magzine, March 17, 1980.
		3. Shaping Life in The Lab, Time Magzine, March 9, 1981.
		4. Immune Systems of "Bubble Baby" Restored by Gene Therapy, UCLA News, September 14, 2012.
		5. Gene Therapy Cures Adult Leukemia, WebMD, August 10, 2011.
		6. Gene Therapy Proves Effective For Hemophilia B, Reuters, December 10, 2011.
		7. Want to Know My Future?, Time Magzine, December 24, 2012.
		8. Entire DNA of Fetus Revealed Through Risk-Free Testing, Los Angeles Time, June 12, 2012.
		9. Scientist Creates Life - That's a Good Thing, Right?, Time Magzine, May 20, 2010.
	Discussion Two: Scientific Origins of Genetic Engineering & Biotechnology (click here to download the articles)
		1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
		2. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.
	Discussion Three: Crop Genetic Engineering (click here to download the articles)
		1. Charles S. Gasser and Robert T. Fraley, Transgenic Crops, Scientific American, June, 1992, 266(6), 62-69.
		2. USDA Economic Service Report on the Adoption of Genetically Engineered Crops, 2012.
		3. Terry Raney and Prabhu Pingali, Sowing a Gene Revolution, Scientific American, September, 2007, 297(3), 104-111.
		4. Golden Rice, Time Magazine, July 31, 2000.
		5. Amy Maxmen, Drug Making Plant Blooms, Nature, May 10, 2012, 485, 160.
		6. Mark Lynas Oxford Farming Lecture, "Apologies From an Anti-GMO Activist," January 3, 2013.
	Discussion Four: How to Mark Your Genes (click here to download the articles)
		1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
		2. Mark A. Rothstein, Keeping Your Genes Private, Scientific American, September 2008, 299(3), 64-69.
		3. Want to Know My Future?, Time Magzine, December 24, 2012.
		4. Entire DNA of Fetus Revealed through Risk-Free Testing, Los Angeles Times, June 12, 2012.
		5. Areil Bleicher, Perils of Newborn Screening, Scientific American, July 12, 2012, 307(1), 30-31.
	Discussion Five: DNA and the Law (click here to download the articles)
		1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
		2. Caitlin Smith, Stephen Strauss, & Laura DeFrancesco, DNA Goes to Court, Nature Biotechnology, November, 2012, 30(11), 1047-1052.
	Discussion Six: Animal Genetic Engineering (click here to download the articles)
		1. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
		2. Gary Stix, The Land of Milk & Honey, Scientific American, November 2005, 293(5), 102-104.
		3. New Antithrombin Drug, ATryn, Approved by FDA, National Blot Clot Alliance Website.
		4. Ian Wilmot, Cloning For Medicine, Scientific American, December 1998, 279(6), 58-63.
		5. GM Salmon: FDA's Assessment of Risks, Los Angeles Times, December 24, 2012.
		6. Amy Maxmen, Politics Holds Back Animal Engineers, Nature, October 18, 2012, 490, 318-319.
	Discussion Seven: Stem Cells: Studying and Genetic Engineering (click here to download the articles)
		1. Clive Cookson et al., The Future of Stem Cells. Scientific American Special Report, July, 2005, A6-A21.
		2. Konrad Hochedlinger, Your Inner Healers. Scientific American, May, 2010, 302(4), 47-53.
		3. Stephen S. Hall, Diseases in a Dish. Scientific American, March, 2011, 304(3), 41-45.
		4. Robin Marantz Henig, Pandora's Baby. Scientific American, June, 2003, 266(6), 63-68.
		5. High Court Rejects Stem Cell Challenge. Los Angeles Times, January 8, 2013.
	Discussion Eight: Human Genetic Engineering (click here to download the articles)
		1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
		2. Steve Mirsky & John Rennie, What Cloning Means for Gene Therapy? Scientific American, June, 1997, 276(6), 122-123.
		3. Gary Stix, Hitting the Genetic Off Switch. Scientific American, October, 2004, 291(4), 98-101.
		4. Immune Systems of "Bubble Baby" Restored by Gene Therapy. UCLA News, September 14, 2012.
		5. Gene Therapy Cures Adult Leukemia. WebMD, August 10, 2011.
		6. Gene Therapy Proves Effective For Hemophilia B. Reuters, December 10, 2011.
	Discussion Nine: Genes and Cancer (click here to download the articles)
		1. Webster K. Cavenee & Raymond L. White, The Genetic Basis of Cancer, Scientific American, March 1995, 273(3), 72-79.
		2. Francis S. Collins & Anna D. Barker, Mapping the Cancer Genome, Scientific American, March 2007, 296(3), 50-57.
		3. Gene Therapy Cures Adult Leukemia. WebMD, August 10, 2011.
	Discussion Ten: Patenting Genes (click here to download the articles)
		1. Science: Test-Tube Life: Reg. U.S. Pat. Office, Time Magazine, June 30,1980.
		2. Gary Stix, Owning the stuff of Life, Scientific American, February, 2006, 294(2), 76-83.
		3. John J. Doll, Talking Gene Patents, Scientific American, August, 2001, 265(2) 28.
		4. Ruling Upholds Gene Patent in Cancer Test, New York Times, July 29, 2011.
		5. Supreme Court to Look at Gene Patent Issue, New York Times, November 30, 2012.