Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Spring 2017


Professor Bob Goldberg

SPONSORED BY

Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tuesday & Thursday : 3:30 - 6:00 PM
  Location: La Kretz 120
  Discussions: Wednesday: 2:00 - 3:50 PM (La Kretz 100)
Wednesday: 4:00 - 5:50 PM (La Kretz 100)
Wednesday: 6:00 - 7:50 PM (La Kretz 100)

  Office Hours: Thursday: 1:30PM - 2:30PM Dr. Bob Goldberg (Terasaki Life Sci 4121)
Class Syllabus

 
 

Class Handouts and Powerpoint Presentation

Week 1

 

04/04/17 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One)
04/06/17 - Film:  Gene Engineers: Playing God

 

Week 2

 

04/11/17 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two)
04/13/17 - Film:  Race for the Double Helix

 

Week 3

 

04/18/17 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One)
04/20/17 - Film:  Extraodinary Measures

 

Week 4

 

04/25/17 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two)
04/27/17 - Guest Speaker: Engineering Crops For the Developing World by Dr. Prakash
                                            GMOs - What's All the Fuss About? by Dr. McHughen

 

Week 5

 

05/02/17 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Hemophilia Story
05/04/17 - Guest Speaker: DNA Forensics Analysis & The Law by Harry Klann from LAPD DNA Unit

 

Week 6

 

05/09/17 - All-Class Midterm Oral Exam
05/11/17 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications

 

Week 7

 

05/16/17 - Lecture Seven Handout (pdf): Age of Genomics - Three Parent Babies, Human Origins, & Race
05/18/17 - Guest Speaker: In Vitro Fertilization & Genetic Testing by Dr. Michele Evans

 

Week 8

 

05/23/17 - Lecture Eight Handout (pdf) by Dr. John Harada: Human Genetic Engineering & Gene Therapy
05/25/17 - Guest Speaker: Stem Cell Biology and Ethics by Dr. Pei Yun Lee

 

Week 9

 

05/30/17 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & GMO
06/01/17 - Guest Speaker: The Future of Genetic Engineering & Health by Dr. Daisy Robinton

 

Week 10

 

06/06/17 - Lecture Ten Handout (pdf): Science & the Constitution: Who Owns Your Genes
06/08/17 - All-Class Final Oral Exam

 
 
Articles For Discussion
 
Discussion One: What Do You Think About GMO?
 
Discussion Two: Origins of Genetic Engineering - 1
   
1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
   
2. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July, 1977, 237(1), 22-33.
 
Discussion Three: Origins of Genetic Engineering - 2
   
1. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.

Discussion Four: Genetic Engineering Crops & Farm Animals
   
1. David H. Freedman, Are Engineered Foods Evil?, Scientific American, September, 2013, 80-85.
   
2. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
   
3. GM Salmon: FDA's Assessment of Risks, Los Angeles Times, December 24, 2012.
 
Discussion Five: DNA and the Law
   
1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
   
2. Caitlin Smith, Stephen Strauss, & Laura DeFrancesco, DNA Goes to Court, Nature Biotechnology, November, 2012, 30(11), 1047-1052.
 
Discussion Six: How to Mark Your Genes
   
1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
   
2. Kevin A. Strauss, Genomics for the People, Scientific American, December 2015, 313(6), 66-73.
 
Discussion Seven: The CRISPR Revolution
   
1. Michael Specter, DNA Revolution, National Geographic Magzine, August 2016, 31-55.
   
2. Michael Specter, The Gene Hackers, The New Yorker, November 16, 2015.
 
Discussion Eight: Human Genetic Engineering
   
1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
   
2. Rick Lewis, Gene Therapy's Second Act Scientific American, March 1, 2014, 310(3).
 
Discussion Nine: Synthetic Biology
   
1. Michael Waldholz, Future of Medicine: Transformers, Scientific American, April 2017, 46-53.
   
2. Nicola Twilley, What's The Point of Streamlining Nature?, The New Yorker, April 2 2016.
   
3. Andrew Pollack, Scientists Hold Secret Meeting to Consider Creating a Synthetic Human Genome, The New York Times, May 13 2016.
 
Discussion Ten: Patenting Genes
   
1. John S. Demott, Science: Test-Tube Life: Reg. U.S. Pat. Office, Time Magazine, June 30,1980.
   
2. Gary Stix, Owning the stuff of Life, Scientific American, February, 2006, 294(2), 76-83.
   
3. Adam Liptak, Justics, 9-0, Bar Patenting Human Genes, New York Times, June 13, 2013.
   
4. Antonio Regalado, CRISPR Patent Fight Now a Winner-Take-All Match, MIT Technology Review, April 15, 2015.
   
5. Andrew Pollack, Harvard and MIT Scientists Win Gene-Editing Patent Fight, New York Times, February. 15, 2017.