Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2008


Professor Bob Goldberg

SPONORED BY



Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:30 - 5:50 PM
  Discussions: Wed : 2:00 - 4:00 PM TA Brandon Le (La Kretz 101)
Wed : 4:00 - 6:00 PM TA Daisy Robinton (La Kretz 101)
Wed : 6:00 - 8:00 PM TA Rebekah Charney (LS 2320)
  Location: La Kretz 120
 
Class Video
Class Syllabus
 

Class Handouts and Powerpoint Presentation

 

01/08/08 - Lecture-1 Handout(pdf): The Age of DNA: What is Genetic Engineering?

 

01/15/08 - Lecture-2 Handout(pdf): What Are Genes & How Do They Work: Part One

 

01/17/08 - Lecture-3 Handout(pdf): What Are Genes & How Do They Work: Part Two

 

01/22/08 - Lecture-4 Handout(pdf): The Nuts & Bolts of Genetic Engineering

 

01/29/08 - Lecture-5 Handout(pdf): The Age of Genomics: Your Personal Genome

 

02/12/08 - Lecture-6 Handout(pdf): Identifying Human Origins: Past and Present - Part I

 

02/19/08 - Lecture-6 Handout(pdf): Identifying Human Origins: Past and Present - Part II

 

02/26/08 - Lecture-7 Handout(pdf): 21st Century Genetic Engineering Applications - Part I

 

02/28/08 - Lecture-7 Handout(pdf): 21st Century Genetic Engineering Applications - Part II

 

03/04/08 - Lecture-8 Handout(pdf): Science and the Constitution: Regulating Science and Genetic Engineering

 

03/11/08 - Lecture-9 Handout(pdf): Science and the Constitution: Who Owns Your Genes?

 

Class Announcements

 

Week One - 01/08/08

 

Week One - 01/10/08

 

Week Two - 01/15/08

 

Week Two - 01/17/08

 

Week Three - 01/22/08

 

Week Three - 01/24/08

 

Week Four - 01/29/08

 

Week Four - 01/31/08

 

Week Five - 02/07/08

 

Week Six - 02/12/08

 

Week Six - 02/14/08

 

Week Seven - 02/19/08

 

Week Seven - 02/21/08

 

Week Eight - 02/26/08

 

Week Eight - 02/28/08

 

Week Nine - 03/04/08

 

Week Nine - 03/06/08

 
Guest Speakers (Click on the name for information about the speaker)
  Dr. Alan McHughen, Ph.D.
Department of Plant Sciences, University of California, Riverside
Title: The AgBiotech Controversy [pdf]

  Dr. Richard Hamilton, Ph.D.
President and CEO, Ceres, Inc. Thousand Oaks, CA
Title: BioFuels: Growing Energy [pdf]
  Officer Harry Klann
Criminologist, Los Angeles Police Department
Title: DNA Forensics & the Law [pdf]
  Dr. Susan Sarajari, M.D., Ph.D.
Ob/Gyn & Reprodcutive Endocrinologist, Huntington Reproductive Center
Title: Infertility, In Vitro Fertilization (IVF) and Genetic Testing [pdf]
  Dr. Gregory Stock, Ph.D.
CEO and President, Signum Biosciences, Princeton, NJ
Title: Ethical Issues in Human Genetics and Cloning
 
Articles For Discussion
 
Discussion One: The Basics of Genetic Engineering
   

Stanley N. Cohen
The Manipulation of Genes.
Scientific American, July, 1975, 233 (1), 24-33.

   
Clifford Grobstein
The Recombinant DNA Debate.
Scientific American, July, 1977, 237 (1) 22-33.
   
Berg et al.
Potential Biohazards of Recombinant DNA Molecules.
Science, New Series, Vol. 185, No. 4148 (Jul. 26, 1974), 303.
 
Discussion Two: Using Genetic Engineering to Make Drugs in Bacteria
   
Walter Gilbert and Lydia Villa-Komaroff
Useful Proteins From Recombinant Bacteria.
Scientific American, April, 1980, 242 (4), 74-94.
   
William A. Haseltine
Discovering Genes For New Medicine.
Scientific American, March, 1997, 276 (3), 92-97.
   
Ken Howard
The Bioinformatics Gold.
Scientific American, July 2000, 282 (1), 58-63.
 
Discussion Three: Using Genetic Engineering to Make Better Crops.
   
Charles S. Gasser and Robert T. Fraley
Transgenic Crops..
Scientific American, June, 1992, 266 (6), 62-69.
   
Terri Raney and Prabhu Pingali
Sowing a Gene Revolution..
Scientific American, September, 2007, 297 (3), 104-111.
   
Kathryn Brown
Seeds of Concern..
Scientific American, April, 2001, 284 (4), 52-57.

Discussion Four: Identifying and Testing for Human Disease Genes
   
Ray White and Jean-Marc Lalouel
Chromosome Mapping with DNA Markers.
Scientific American , February, 1988, 258 (2), 40-48.
   
John Rennie
Grading the Gene Tests.
Scientific American , June, 1994, 270 (6), 89-97.
 
Discussion Five: DNA Testing in the Courtroom
   
Peter J. Neufeld and Neville Colman
When Science Takes the Witness Stand.
Scientific American, May, 1990, 262 (5), 46-53.
   
Jerry Adler and John McCormick
The DNA Detectives.
Newsweek, November 16, 1998, pgs.64-71.
   
 
Discussion Six: Genetic Engineering Farm Animals to Make Drugs
 
William H. Velander, Henryk Lubon, and William N. Drohan
Thansgenic Livestock as Drug Factories.
Scientic American, January, 1997, 276 (1), 70-74.
   
Ian Wilmot
Cloning For Medicine.
Scientific American, December 1998, 279 (6), 58-63.
   
Gary Stix
The Land of Milk & Honey
Scientific American, November 2005, 293 (5), 102-104.
 
Discussion Seven: Embryonic Stem Cell and Cloning for Medicine
   
Roger A. Pedersen
Embryonic Stem Cells For Medicine..
Scientific American, April 1999, 280 (4), 68-73.
   
Clive Cookson et al.,
The Future of Stem Cells..
Scientific American Special Report, July 2005, A6-A21.
   
Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo.
Scientific American, January, 2002, 286 (1), 44-51.
   
Robin Marantz Henig
Pandora's Baby
Scientific American, June, 2003, 266 (6), 63-68. 
 
Discussion Eight: Understanding and Defeating Cancer
   
Webster K. Cavenee and Raymond L. White
The Genetic Basis of Cancer..
Scientific American, March 1995, 273 (3), 72-79.
   
Stephen H. Friend and Roland B. Stoughton
The Magic of Microarrays.
Scientific American, February, 2002, 286 (2), 44-53.
   
Francis S. Collins and Anna D. Barker
Mapping the Cancer Genome.
Scientific American, October, 2007, 296 (3), 50-57.
 
Discussion Nine: Counteracting Bioweapons
   
Mathew Meselson
Chemical and Biological Weapons.
Scientific American, May, 1970, 222 (5), 15-25.
   
John T. Young and R. John Collier
Attacking Anthrax.
Scientific American, March, 2002, 286 (3), 48-59.
   
Rocco Casagrande
Technology Against Terror.
.
Scientific American, October, 2002, 287 (3), 83-87.
 
Discussion Ten: Gene Therapy: Fixing Human Genetic Defects
   
   
Theodore Friedman
Overcoming the Obstacles to Gene Therapy.
Scientific American, June, 1997, 276 (6), 96-101.
   
Steve Mirsky and John Rennie
What Cloning Means for Gene Therapy?
Scientific American, June, 1997, 276 (6), 122-123.