Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2011


Professor Bob Goldberg

SPONSORED BY



Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:30 - 6:00 PM
  Discussions: Wed : 1:00 - 2:50 PM Elaine Chiu (La Kretz 100)
Wed : 3:00 - 4:50 PM Lulu Pantin (La Kretz 100)
Wed : 5:00 - 6:50 PM Eden Maloney (La Kretz 100)
  Location: La Kretz 120
 
Class Video
Class Syllabus
 

Class Handouts and Powerpoint Presentation

Week 1

 

01/04/11 - Lecture-1 Handout(ppt): The Age of DNA: What is Genetic Engineering?

01/06/11 - Film:  Race for the Double Helix

 

Week 2

 

01/11/11 - Lecture-2 Handout(ppt): The Age of DNA: What is Genetic Engineering: Part Two

 

01/13/11 - Guest Speaker Handout(ppt) by Robert Wayne: Hunting for Canine Ancestors and Engineering Modern-Day Dogs

Week 3

 

01/18/11 - Lecture-3 Handout(ppt): What Are Genes & How Do They Work: Part One

 

01/20/11 - Guest Speaker Handout(ppt) by Richard Hamilton: Engineering Plants For Biofuels

Week 4

 

01/25/11 - Lecture-4 Handout(ppt): What Are Genes & How Do They Work: Part Two

 

01/27/11 - Guest Speaker Handout(ppt) by Channapatna Prakash: Engineering Crops for the Developing World

Week 5

 

02/01/11 - Lecture-5 Handout(ppt): The Nuts & Bolts of Genetic Engineering:The Factor VIII Story - From Gene To Drug

 

02/03/11 - Guest Speaker Handout(ppt) by Harry Klann: An Introduction to DNA Forensic Analysis

Week 6

 

02/10/11 - Lecture-6 Handout(ppt): The Age of Genomics: Your Personal Genome & Tracing Your Ancestry

Week 7

 

02/15/11 - Lecture-7 Handout(ppt): The Age of Genomics: Your Personal Genome & Tracing Your Ancestry Part 2

 

02/17/11 - Guest Speaker Handout (ppt) by Pei Yun Lee: Stem Cells - Hype vs. Reality

Week 8

 

02/22/11 - Lecture-8 Handout(ppt): Human Genetic Engineering and Gene Therapy

 

02/24/11 - Guest Speaker Handout(ppt) by Michele Evans: Infertility, In-vitro Fertilization, and Genetic Testing

Week 9

 

03/01/11 - Lecture-9 Handout(ppt): Science and the Constitution: Regulating Science & Genetic Engineering

Week 10

 

03/8/11 - Lecture 10 Handout(ppt): Science and the Constitution: Who Owns Your Genes?

 
Guest Speakers (Click on the name for information about the speaker)
  Dr. Robert Wayne, Ph.D.
UCLA Professor in the Department of Ecology and Evolutionary Biology
Title: Hunting for Canine Ancestors and Engineering Modern-Day Dogs
  Dr. Richard Hamilton, Ph.D.
President and CEO, Ceres, Inc. Thousand Oaks, CA
Title: Engineering Plants For BioFuels
  Dr. Channapatna Prakash, Ph.D.
Professor in Plant Molecular Genetics, Tuskegee University
Title: Engineering Crops for the Developing World

  Harry Klann
Supervising Criminalist, LAPD
Title: DNA Forensics and the Law
  Dr. Pei Yun Lee, Ph.D.
UCLA Department of Molecular, Cell, and Developmental Biology
Title: Stem Cells--Promise, Reality, and Conflict
  Dr. Michele Evans, M.D., FACOG
Reproductive Specialist, Huntington Reproductive Center
Title: In Vitro Fertilization (IVF), and Genetic Testing
  Dr. John Novembre, Ph.D.
Assistant Professor, Department of Ecology and Evolutionary Biology, UCLA
Title: Tracking Human Ancestry
 
Articles For Discussion
 
Discussion One: The Basics of Genetic Engineering
   

Stanley N. Cohen
The Manipulation of Genes.
Scientific American, July, 1975, 233 (1), 24-33.

   
Clifford Grobstein
The Recombinant DNA Debate.
Scientific American, July, 1977, 237 (1) 22-33.
   
Berg et al.
Potential Biohazards of Recombinant DNA Molecules.
Science, New Series, Vol. 185, No. 4148 (Jul. 26, 1974), 303.
 
Discussion Two: Using Genetic Engineering to Make Drugs in Bacteria
   
Walter Gilbert and Lydia Villa-Komaroff
Useful Proteins From Recombinant Bacteria.
Scientific American, April, 1980, 242 (4), 74-94.
   
William A. Haseltine
Discovering Genes For New Medicine.
Scientific American, March, 1997, 276 (3), 92-97.
 
Discussion Three: Using Genetic Engineering to Make Better Crops.
   
Charles S. Gasser and Robert T. Fraley
Transgenic Crops.
Scientific American, June, 1992, 266 (6), 62-69.
   
Terri Raney and Prabhu Pingali
Sowing a Gene Revolution.
Scientific American, September, 2007, 297 (3), 104-111.
   
George W. Huber and Brice E. Dale
Grassoline at the Pump.
Scientific American, July, 2009, 52-61.
   
C.S. Prakash
The Genetically Modified Crop Debate

Plant Physiology, Vol. 126 (May 2001), 8-15.

Discussion Four: Identifying and Testing for Human Disease Genes
   
Ray White and Jean-Marc Lalouel
Chromosome Mapping with DNA Markers.
Scientific American , February, 1988, 258 (2), 40-48.
   
Mark A. Rothstein
Keeping Your Genes Private.
Scientific American , September, 2008, 299 (3), 64-69.
 
Discussion Five: DNA Testing in the Courtroom
   
Peter J. Neufeld and Neville Colman
When Science Takes the Witness Stand.
Scientific American, May 1990, 262 (5), 46-53.
   
Sheldon Krimsky and Tania Simoncelli
DNA and Justice Denied.
LA Times, December 22, 2010.
   
Greg Miller
Familial DNA Testing

Science, Vol. 329, (July 16, 2010), 262.
   
Christine Soares
Portrait in DNA

Scientific American, (May 2010), 14&17.
 
Discussion Six: Genetic Engineering Farm Animals to Make Drugs
 
William H. Velander, Henryk Lubon, and William N. Drohan
Transgenic Livestock as Drug Factories.
Scientic American, January, 1997, 276 (1), 70-74.
   
Ian Wilmot
Cloning For Medicine.
Scientific American, December 1998, 279 (6), 58-63.
   
Gary Stix
The Land of Milk & Honey
Scientific American, November 2005, 293 (5), 102-104.
   
Richard M. Lawn and Gordon A. Vehar
The Molecular Genetics of Hemophilia
Scientific American, March 1986, 254 (3), 48-54.
   
Nuffield Council on Bioethics
The Forensic Use of Bioinformation: Ethical Issues
www.nuffieldbioethics.org/bioinformation.
 
Discussion Seven: Embryonic Stem Cell and Cloning for Medicine
   
Clive Cookson et al.,
The Future of Stem Cells..
Scientific American Special Report, July 2005, A6-A21.
   
Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo.
Scientific American, January 2002, 286 (1), 44-51.
   
Robin Marantz Henig
Pandora's Baby
Scientific American, June 2003, 266 (6), 63-68. 
   
Konrad Hochedlinger
Your Inner Healers
Scientific American, May 2010, 47-53. 
 
Discussion Eight: Human Genetic Engineering and Gene Therapy
   
   
Theodore Friedman
Overcoming the Obstacles to Gene Therapy.
Scientific American, June, 1997, 276 (6), 96-101.
   
Steve Mirsky and John Rennie
What Cloning Means for Gene Therapy?
Scientific American, June, 1997, 276 (6), 122-123.
 
Discussion Nine: Science and the Constitution: Regulating Science and GMOs
   
Gary Stix
Traces of a Distant Past
Scientific American, July 2008, 298 (6), 56-63.
   
Jonathan K. Pritchard
How We Are Evolving
Scientific American, October 2010, 303 (4), 41-47.
 
Discussion Ten: Science and the Constitution: Who Owns Your Genes?
   
Webster K. Cavenee and Raymond L. White
The Genetic Basis of Cancer..
Scientific American, March 1995, 273 (3), 72-79.
   
Francis S. Collins and Anna D. Barker
Mapping the Cancer Genome.
Scientific American, October, 2007, 296 (3), 50-57.