HC70A_W12 Course Document

Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2012

Professor Bob Goldberg

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Course Documents


Course Info:
	Units:	5.0
	Lectures:	Tues & Thurs : 3:30 - 6:00 PM
	Discussions:	Wed : 1:00 - 2:50 PM Eden Maloney (La Kretz 100) Wed : 3:00 - 4:50 PM Elaine Chiu (La Kretz 100) Wed : 5:00 - 6:50 PM Lulu Pantin (La Kretz 100)
	Location:	La Kretz 120

Class Video		Watch Movie
Class Syllabus		Download File

Class Handouts and Powerpoint Presentation
Week 1
	01/10/12 - Lecture-1 Handout(ppt): The Age of DNA: What is Genetic Engineering? (Part One) 01/12/12 - Film: Race for the Double Helix

Week 2
	01/17/12 - Lecture-2 Handout(ppt): The Age of DNA: What is Genetic Engineering? (Part Two) 01/19/12 - Film: The Lysenko Affair; History's Harvest: Anti-Science

Week 3
	01/24/12 - Lecture-3 Handout(ppt): What Are Genes & How Do They Work: (Part One)
	01/26/12 - Guest Speaker Handout(ppt) by C.S. Prakash: Engineering Crops for the Developing World
Week 4
	01/31/12 - Lecture-4 Handout(ppt): What Are Genes & How Do They Work: (Part Two)
	02/02/12 - Guest Speaker Handout(ppt) by Harry Klann: An Introduction to Forensic DNA Analysis & Crime Scene Investigation
Week 5
	02/07/12 - Lecture-5 Handout(ppt): What Are Genes & How Do They Work (Part 3)
	02/09/12 - Guest Speaker Handout(ppt) by Robert Wayne: Engineering of the Dog and Its Wild Relatives
Week 6
	02/16/12 - Lecture-6 Handout(ppt): The Nuts & Bolts of Genetic Engineering: The Factor VIII Story - From Gene to Drug
Week 7
	02/21/12 - Lecture-7 Handout(ppt): Your Personal Genome & Tracing Your Ancestry Part
	02/23/12 - Guest Speaker Handout (ppt) by Pei Yun Lee: Stem Cell Biology and Ethics
Week 8
	02/28/12 - Lecture 8 Handout (ppt) by John Harada: Human Genetic Engineering and Gene Therapy
	03/01/12 - Guest Speaker Handout(ppt) by Michele Evans: Infertility, In-vitro Fertilization, and Genetic Testing
Week 9
	03/06/12 - Lecture-9 Handout(ppt): Science and the Constitution: Regulating Science & Genetic Engineering 03/08/12 - Film: Extraordinary Measures
Week 10
	03/13/12 - Lecture 10 Handout(ppt): Science and the Constitution: Who Owns Your Genes?

Guest Speakers (Click on the name for information about the speaker)
	Dr. Channapatna Prakash, Ph.D. Professor in Plant Molecular Genetics, Tuskegee University Title: Engineering Crops for the Developing World
	Harry Klann Supervising Criminalist, LAPD Title: An Introduction to Forensic DNA Analysis & Crime Scene Investigation
	Dr. Robert Wayne, Ph.D. UCLA Professor in the Department of Ecology and Evolutionary Biology Title: Engineering of the Dog and Its Wild Relatives/font>
	Dr. PeiYun Lee, Ph.D. UCLA Department of Molecular, Cell, and Developmental Biology Title: Stem Cells - Promise, Reality, and Conflict
	Dr. Michele Evans, M.D., FACOG Reproductive Specialist, Pacific Fertility Center Los Angeles Title: In Vitro Fertilization (IVF), and Genetic Testing

Articles For Discussion
	Discussion One: The Basics of Genetic Engineering
		Stanley N. Cohen The Manipulation of Genes. Scientific American, July, 1975, 233 (1), 24-33.
		Clifford Grobstein The Recombinant DNA Debate. Scientific American, July, 1977, 237 (1) 22-33.
		Frederic Golden Shaping Life in the Lab. Time Magazine, March 9, 1981, 1-13.
	Discussion Two: Using Genetic Engineering to Make Drugs in Bacteria
		Walter Gilbert and Lydia Villa-Komaroff Useful Proteins From Recombinant Bacteria. Scientific American, April, 1980, 242 (4), 74-94.
	Discussion Three: Using Genetic Engineering to Make Better Crops.
		Charles S. Gasser and Robert T. Fraley Transgenic Crops. Scientific American, June, 1992, 266 (6), 62-69.
		Terri Raney and Prabhu Pingali Sowing a Gene Revolution. Scientific American, September, 2007, 297 (3), 104-111.
		William H.R. Langridge Edible Vaccines. Scientific American, September, 2000, 283 (3), 66-71.
		C.S. Prakash The Genetically Modified Crop Debate Plant Physiology, Vol. 126 (May 2001), 8-15.
	Discussion Four: Identifying and Testing for Human Disease Genes
		Ray White and Jean-Marc Lalouel Chromosome Mapping with DNA Markers. Scientific American , February, 1988, 258 (2), 40-48.
		Mark A. Rothstein Keeping Your Genes Private. Scientific American , September, 2008, 299 (3), 64-69.
		Melinda W. Moyer Too Much Information. Scientific American , April, 2011, 304 (4), 27.
	Discussion Five: DNA Testing in the Courtroom
		Peter J. Neufeld and Neville Colman When Science Takes the Witness Stand. Scientific American, May 1990, 262 (5), 46-53.
		Sheldon Krimsky and Tania Simoncelli DNA and Justice Denied. LA Times, December 22, 2010.
		Greg Miller Familial DNA Testing Science, Vol. 329, (July 16, 2010), 262.
		Christine Soares Portrait in DNA Scientific American, (May 2010), 14&17.
		Editors Stop The DNA Dragnet Scientific American, (December 2011), 305 (6), 14.
	Discussion Six: Using Genetic Engineering to Make Drugs in Farm Animals
		William H. Velander, Henryk Lubon, and William N. Drohan Transgenic Livestock as Drug Factories. Scientic American, January, 1997, 276 (1), 70-74.
		Ian Wilmot Cloning For Medicine. Scientific American, December 1998, 279 (6), 58-63.
		Gary Stix The Land of Milk & Honey Scientific American, November 2005, 293 (5), 102-104.
	Discussion Seven: Stem Cells: Studying and Curing Human Diseases/b>
		Clive Cookson et al., The Future of Stem Cells Scientific American Special Report, July 2005, A6-A21.
		Konrad Hochedlinger Your Inner Healers Scientific American, May 2010, 302 (4), 47-53.
		Stephen S. Hall Diseases in a Dish Scientific American, March 2011, 304(3) 41-45.
		Robin Marantz Henig Pandora's Baby Scientific American, June 2003, 266 (6), 63-68.
	Discussion Eight: Human Genetic Engineering and Gene Therapy
		Inder M. Verma Gene Therapy. Scientific American, November, 1990, 263 (5), 68-84.
		Theodore Friedman Overcoming the Obstacles to Gene Therapy. Scientific American, June, 1997, 276 (6), 96-101.
		Matthew P. Morrow and David B. Weiner DNA Drugs Come of Age Scientific American, July, 2010, 303 (1), 48-53.
		Steve Mirsky and John Rennie What Cloning Means for Gene Therapy? Scientific American, June, 1997, 276 (6), 122-123.
	Discussion Nine: Using DNA to Trace Ancestry and Human Origins
		Gary Stix Traces of a Distant Past Scientific American, July 2008, 298 (6), 56-63.
		Jonathan K. Pritchard How We Are Evolving Scientific American, October 2010, 303 (4), 41-47.
		Emily Anthes 3 Diseases We May Be Able to Blame on Our Ancient Ancestors Discover Magazine, December 2008.
	Discussion Ten: Understanding and Defeating Cancer
		Webster K. Cavenee and Raymond L. White The Genetic Basis of Cancer.. Scientific American, March 1995, 273 (3), 72-79.
		Jeff Wheelwright Cancer's Wandering Genes. Discover Magazine, December 2011, 64-70.
		Francis S. Collins and Anna D. Barker Mapping the Cancer Genome. Scientific American, October, 2007, 296 (3), 50-57.