The growth plate is one of the few tissues in vertebrates in which cells are stratified according to their differentiation status. This makes it possible to use phenotypic analysis of mice to investigate the functions of genes in specific aspects of commitment, maintenance, proliferation, differentiation...(more)

Signaling pathways controlling formation of the growth plate

Matricellular proteins have been defined as residing in the ECM, but having regulatory rather than structural roles. The CCN family of matricellular proteins includes connective tissue growth factor (CCN2/CTGF), CCN1/Cyr61, CCN3/NOV, and CCN4/Wisp1...(more)

CCN protein function

Cartilage and bone formation

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Matricellular Proteins

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Osteoarthritis is the leading cause of long-term disability in the United States...(more)

Implications

Department of Molecular, Cell and Developmental Biology

UCLA/ Orthopaedic Hospital Department of Orthopaedic Surgery