Publications (selected)

Click *here* for PubMed publication list for K.M. Lyons.

Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. (2012) CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis. PLoS One. 2012;7(2):e30562.

Hall-Glenn F, Lyons KM. (2011) Roles for CCN2 in normal physiological processes. Cell Mol Life Sci. 68(19):3209-17.

Estrada KD, Retting KN, Chin AM, Lyons KM. (2011) Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res. 26(10):2498-510.

Huang BL, Brugger SM, Lyons KM. (2010) Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem. 285(36):27702-12.

Song B, Estrada KD, Lyons KM. (2009) Smad signaling in skeletal development and regeneration.Cytokine Growth Factor Rev. 20:379-88.

Retting KN, Song B, Yoon BS, Lyons KM. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for edochondral bone formation. Development.136:1093-104.

Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M. (2009) CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 44:24-31.

Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. (2008) Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res.11:1751-64.

Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. (2007) CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal. 1:45-58.

Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. (2006) BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development.133:4667-78.

Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT. (2006) Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A. 103:12335-40.

Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR. (2006) Tracking expression of virally mediated BMP-2 in gene therapy for bone repair. Clin Orthop Relat Res. 450:238-45.

Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. (2005) BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A.102:18023-7.

Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. (2005) GDF11 controls the timing of progenitor cell competence in developing retina. Science 308:1927-30.

Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 102:5062-7.

Yoon BS, Lyons KM. (2004) Multiple functions of BMPs in chondrogenesis. J Cell Biochem. 93:93-103.

Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development.130:2779-91.

Lyons Lab