Publications
Langenbacher A Nguyen CT, Cavanaugh A, Huang J, Lu F and Chen JN (2011) The PAF1 complex differentially regulates cardiomyocyte specification. Developmental Biology, 353: 19-28.
Choi J, Mouillesseaux K, Wang Z, Fiji HDG, Kinderman SS, Otto FW, Geisler R, Kwon O and Chen JN (2011) Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Development, 138: 1173-1181.
Sun H, Lu G, Ren V, Chen JN and Wang Y (2011) Catabolism of branched-chain amino acids in heart failure: insights from genetic models. Journal of Pediatric Cardiology 32:305-310.
Yu F, Huang J, Adlerz K, Jadvar H, Hamdan M, Chen JN and Hsiai T (2010) Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity. Zebrafish, 7: 325-331.
Nguyen C*, Langenbacher A*, Hsieh M and Chen JN (2010) The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish. Developmental Biology, 341: 167-175.
* equal contribution.
Nguyen CT, Lu Qing, Wang Y and Chen JN (2009) Zebrafish as a model for cardiovascular development and disease. Drug Discovery Today: Disease Models, 5: 135-140.
Wilson CW*, Nguyen C*, Chen MH, Yang JH, Gacayan R, Chen JN and Chuang PT (2009) Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature 459: 98-102. * equal contribution.
Colantonio JR, Vermot J, Wu D, Langenbacher AD, Fraser S, Chen JN, Hill KL (2009) The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature: 457:205-210.
Langenbacher AD and Chen JN (2008) Calcium signaling: A common tread in vertebrate left-right axis development. Developmental Dynamics: 237: 3491-3496.
Langenbacher A and Chen JN (2008) Regulation of Vertebrate Left-Right Axis Development by Calcium. In Gerry Weinmaster ed. The Handbook of Cell Signaling. Elsevier, Inc. pp 1885-1890.
Xie Y, Ottolia M, John S, Chen JN and Philipson KD (2008) Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. Am J Physiol Cell Physiol. 295: C388-393.
Liu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, and Childs, S (2007) A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. PNAS, 104: 13990-13995.
Shu X*, Huang J*, Dong Y*, Choi J, Langenbacher A and Chen JN (2007) Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning. Development, 134: 1921-1930. * equal contribution.
Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y (2007) A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes and Development, 21: 784-796.
Choi J, Dong Y, Ahn J, Daw D and Chen JN (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Developmental Biology, 304: 735 - 744.
Cibrian-Uhalte E, Shu X, Langenbacher A, Chen JN and Abdeliah-Seyfried S (2007) Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. Journal of Cell Biology, 176: 223-230.
Mably JD, Chuang, LP, Serluca, FC, Mohideen MAPK, Chen JN and Fishman, MC (2006) santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish. Development 133: 3139-3146.
Kim HJ, Sumanas S, Palencia-Desai S, Dong Y, Chen JN and Lin S (2006) Genetic analysis of early endocrine pancreas formation in zebrafish. Molecular Endocrinology 20: 194-203.
Beis D, Bartman T, Jin SW, Scott IC, D’Amico LA, Ober EA, Verkade H, Frantsve J, Field HA, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DYR and Jungblut B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development 132, 4193-4204.
Jin SW, Beis D, Mitchell T, Chen JN and Stainier DYR (2005) Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development 132, 5185-5197.
Langenbacher AD*, Dong Y*, Shu X, Choi J, Nicoll DA, Goldhaber JI, Philipson KD and Chen JN (2005) Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. PNAS, 102: 17699 - 17704. * equal contribution.
Chen JN, Crowan DB and Mably J (2005) Cardiogenesis and the regulation of cardiac-specific gene expression. Heart Failure Clin.; 1, 157-170.
Huang H, Zhang B, Hartenstein PA, Chen JN and Lin S (2005) NXT2 is required for embryonic heart development in zebrafish. BMC Developmental Biology, 5: 7.
Mably J, Chen JN, Mohideen MA and Fishman MC (2003) heart of glass regulates the concentric growth of the heart in zebrafish. Current Biology, 13: 2138-2147.
Shu X, Cheng K, Patel N, Chen F, Tsai HJ and Chen JN (2003) Na,K-ATPase is essential for embryonic heart development in the zebrafish. Development, 130: 6165-6173.
Cross LM, Cook MA, Lin S, Chen JN and Rubinstein AL (2003) Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arteriosclerosis, Thrombosis, and Vascular Biology 23: 911-912.
Childs S, Chen JN, Garrity DM and Fishman MC (2002) Patterning of angiogenesis in the zebrafish embryo. Development 129: 973-982.
Peterson RT, Mably JD, Chen J-N and Fishman MC (2001) Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Current Biology 11, 1481-1491.
Chan J, Mably JD, Serluca FC, Chen J-N, Goldstein NB, Thomas MC, Jennifer A. Cleary JA, Brennan C, Fishman MC and Roberts TM (2001) Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. Developmental Biology, 234: 470-482.
Chen J-N, van Bebber F, Goldstein AM, Serluca FC, Jackson D, Childs S, Serbedzija G, Warren KS, Mably JD, Lindahl P, Mayer A, Haffter P and Fishman MC. (2001) Genetic steps to organ laterality in zebrafish. Comparative and Functional Genomics: 2: 60-68.
Chen J-N and Fishman MC (2000) Genetics of heart development. Trends in Genetics 16: 383-388.
Chen J-N and Fishman MC (2000) Genetic dissection of heart development. In Fish, Fly, Worm and man. Ernst Schering Research Foundation, 107-122.
Park M, Lewis C, Turbay D, Chung A, Chen J-N, Evans S, Breitbart RE, Fishman MC, Izumo S and Bodmer R. (1998) Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes. Proc. Natl. Acad. Sci. USA 95: 9366-9371.
Serbedzija GN, Chen J-N, Fishman MC. (1998) Regulation in the heart field of zebrafish. Development 125:1095-1101.
Chen J-N, Fishman MC. (1997) Genetic dissection of heart development. In: Burggren W, Keller B, eds. Development of Cardiovascular System: Molecules to Organisms. Cambridge Press, 7-17.
Chen J-N, van Eeden FJM, Warren KS, Chin AJ, Nüsslein-Volhard C, Haffter P and Fishman MC. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124: 4373 - 4382.
Chin AJ, Chen J-N and Weinberg ES. (1997) Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish. Devel. Genes and Evolu. 207: 107-114.
Stainier DYR, Fouquet B, Chen J-N, Warren K S, Weinstein B M, Meiler S, Mohideen MAPK, Neuhauss SCF, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Driever W and Fishman MC. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123: 285-292.
Chen J-N, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJM, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg C-P, Jiang Y-J, Kane DA, Kelsh RN, Mullins MC and Nusslein-Volhard C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123: 293-302.
Chen J-N and Fishman MC. (1996) Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122: 3809-3816.