HC70A_W16 Course Document

Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2016

Professor Bob Goldberg

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Course Documents


Course Info:
	Units:	5.0
	Lectures:	Tues & Thurs : 3:30 - 6:00 PM
	Location:	La Kretz 120
	Discussions:	Wed : 1:00 - 3:00 PM Dominic Lucido (La Kretz 100) Wed : 3:00 - 5:00 PM Dominic Saadi (La Kretz 100) Wed : 5:00 - 7:00 PM Allen Chung (La Kretz 100)
	Office Hours:	Fri: 1:00PM - 2:00PM Dr. Bob Goldberg (Terasaki Life Sci 4121) Mon: 2:00PM - 4:00PM Dominic Lucido (Hershey Hall 318) Tue: 1:00PM - 3:00PM Dominic Saddi (Terasaki 1000) Thur: 10:00AM - 12:00PM Allen Chung (Terasaki 1000)

Class Video		Watch Movie
Class Syllabus		Download File

Class Handouts and Powerpoint Presentation
Week 1
	01/05/16 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One) 01/07/16 - Film: Gene Engineers: Playing God

Week 2
	01/12/16 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two) 01/14/16 - Film: Race for the Double Helix

Week 3
	01/19/16 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One) 01/21/16 - Guest Speaker Handout (pdf): Engineering Crops For the Developing World by Dr. Prakash GMO and Public Policy by Dr. McHughen

Week 4
	01/28/14 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two) 01/30/14 - Film: Extraordinary Measures

Week 5
	02/02/16 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Hemophilia Story 02/04/16 - Guest Speaker Handout (pdf): An Introduction to DNA Forensics Analysis & Crime Scene Investigation by Harry Klann from LAPD DNA Unit

Week 6
	02/11/16 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications 02/09/16 - All-Class Midterm Oral Exam

Week 7
	02/16/16 - Lecture Seven Handout (pdf): The Human Genome & Tracing Your Ancenstry 02/18/16 - Guest Speaker Handout (pdf): Stem Cell Biology and Ethics by Dr. Pei Yun Lee

Week 8
	02/23/16 - Lecture Eight Handout (pdf) by Dr. John Harada: Human Genetic Engineering & Gene Therapy 02/25/16 - Guest Speaker Handout (pdf): In Vitro Fertilization & Genetic Testing by Dr. Michele Evans

Week 9
	03/01/16 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & Genetic Engineering 03/03/16 - Lecture 10 Handout (pdf): Science & the Law: Who Owns Your Genes?

Articles For Discussion
	Discussion One: Origins of Genetic Engineering - 1 (click here to download the articles)
		1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
		2. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July, 1977, 237(1), 22-33.
		3. Victor McElheny, Amid Gene Editing Worry, A Return To Biotech's 1 st "Asilomar Moment" Xconomy.com, March 26, 2015
	Discussion Two: Scientific Origins of Genetic Engineering (click here to download the articles)
		1. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.
	Discussion Three: Crop Genetic Engineering (click here to download the articles)
		1. Charles S. Gasser and Robert T. Fraley, Transgenic Crops, Scientific American, June, 1992, 266(6), 62-69.
		2. David H. Freedman, Are Engineered Foods Evil?, Scientific American, September, 2013, 80-85.
		3. Mark Lynas, Lecture to Oxford Farming Conference, www.marklynas.org/2013/01/lecture-to-oxford-farming-conference-3-january-2013/.
	Discussion Four: How to Mark Your Genes (click here to download the articles)
		1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
		2. Kevin A. Strauss, Genomics for the People, Scientific American, December 2015, 313(6), 67-73.
		3. Kevin A. Strauss, Genomics Can Improve Health Care--Right Now, Scientific American Health Blog, November 17, 2015.
	Discussion Five: DNA and the Law (click here to download the articles)
		1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
		2. Caitlin Smith, Stephen Strauss, & Laura DeFrancesco, DNA Goes to Court, Nature Biotechnology, November, 2012, 30(11), 1047-1052.
		3. Clyde Haberman, DNA Analysis Exposes Flaws in an Inexact Forensic Science, The New York Times, May 18, 2014.
		4. Cynthia M. Cale, Forensic DNA Evidence is not Infallible,Nature, October 28, 2015, 526, 611.
		5. Tracey Kaplan, Monte Sereno Murder Case Casts Doubts on DNA Evidence, San Jose Mercury News, July 27, 2015.
	Discussion Six: Oral Midterm Exam Preparation
	Discussion Seven: Animal Genetic Engineering and Gene Editing (click here to download the articles)
		1. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
		2. Rosie Mestel, GM Salmon: FDA's Assessment of Risks, Los Angeles Times, December 24, 2012.
		3. CRISPR, The Disruptor Nature, June 4, 2015, 522(1), 20-24.
		4. Amy Harmon, Open Season is Seen in Gene Editing of Animals, New York Times, November 26, 2015.
		5. Andrew Pollack, Jennifer Doudna, A Pioneer Who Helped Simplify Genome Editing New York Times, May 11, 2015.
		6. Sharon Begley, Meet One of the World's Most Groundbreaking Scientists. He's 34., STAT, November 6, 2015.
	Discussion Eight: Human Genetic Engineering (click here to download the articles)
		1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
		2. Rick Lewis, Gene Therapy's Second Act Scientific American, March, 2014, 310(3), 52-57.
		3. Margaret Knox, Is the Gene-Editing Revolution Finally Here, Scientific American, November, 2014, 311(6), 42-46.
		4. Nicholas Wade, Gene Editing Offers Hope for Treating Duchenne Muscular Dystrophy, Studies Find, The New York Times, December 31, 2015.
		5. David Cyranoski, DNA Editing of Human Embryos Alarms Scientists, Scientific American, March 13, 2015.
		6. Arthur L. Caplan, Brendan Parents, Michael Shen & Carolyn Plunkett,No Time to Waste- The Ethical Challenges Created by CRISPR, EMBO Reports, October, 2015, 16(11), 1421-1426.
	Discussion Nine: Patenting Genes (click here to download the articles)
		1. Gary Stix, Owning the stuff of Life, Scientific American, February, 2006, 294(2), 76-83.
		2. Adam Liptak, Justices, 9-0, Bar Patenting Human Genes, New York Times, June 13, 2013.
		3. CRISPR Patent Fight Now a Winner-Take-All Match, MIT Technology Review, April 15, 2015.
		4. Crispr: Scientists' hopes to win Nobel prize for gene-editing technique at risk over patent dispute, Independent, October 2, 2015.