Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2020


Professor Bob Goldberg

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Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tuesday & Thursday : 3:30 - 6:00 PM
  Location: La Kretz 120
  Discussions: Wednesday: 1-3 PM; 3-5 PM; 5-7 PM (La Kretez 100)
  Office Hours: Friday: 1:30PM - 3:00PM Dr. Bob Goldberg (Terasaki Life Sci 4121)
Class Syllabus

 
 

Class Handouts and Powerpoint Presentation

Week 1

 

01/07/20 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One)
01/09/20 - Film:  Race For the Double Helix

 

Week 2

 

01/14/20 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two)
01/16/20 - Films:  The Gene Engineers; Designing Life; Genetic Information Age

 

Week 3

 

01/21/20 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One)
01/23/20 - Film:  Extraordinary Measures

 

Week 4

 

01/28/20 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two)
01/30/20 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Insulin & Hemophilia Story

 

Week 5

 

02/04/20 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications
02/06/20 - Film:  Food Evolution
                  Guest Speaker:  Dr. Channapatna Prakash

 

Week 6

 

02/11/20 - All-Class Midterm Oral Exam
02/13/20 - Guest Speaker:  Harry Klann, Supervising Criminologist, DNA Unit, LAPD, Retired

 

Week 7

 

02/18/20 - Lecture Seven Handout (pdf): Age of Genomics: Three Parent Babies, Human Origins, and Race
02/20/20 - Guest Speaker:  Stem Cell Biology and Ethics by Dr. Pei Yun Lee

 

Week 8

 

02/25/20 - Lecture Eight Handout (pdf): Human Genetic Engineering & Gene Therapy
02/27/20 - Guest Speaker: In Vitro Fertilization and Genetic Testing by Dr. Michele Evans

 

Week 9

 

03/03/20 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & GMO
03/05/20 - Guest Speaker: The Future of Genetic Engineering & Health by Dr. Daisy Robinton

 

Week 10

 

03/10/20 - Lecture Ten Handout (pdf): Science & the Constitution: Who Owns Your Genes
03/12/20 - All-Class Final Oral Exam

 
 
Articles For Discussion
 
Discussion One: What Do You Think About Genetic Engineering and GMOs?
 
Discussion Two: Origins of Genetic Engineering - Hybrid DNA Molecules and Controversy
   
1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
   
2. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July, 1977, 237(1), 22-33.
 
Discussion Three: Origins of Biotechnology - From Genes to Drugs
   
1. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.

Discussion Four: Origins of Biotechnology - From Genes to Drugs
   
1. Richard M. Lawn, & Gordon A. Vehar, The Molecular Genentics of Hemophilia, Scientific American, March, 1986, 254(3), 48-54.

Discussion Five: Genetic Engineering Crops & Farm Animals
   
1. David H. Freedman, Are Geneticcally Engineered Foods Evil?, Scientific American, September, 2013, 80-85.
   
2. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
   
3. Carolyn Y. Johnson, Gene Edited Farm Animals Are Coming, The Washington Post, December 17 2018.
   
4. Emily Waltz, GM Salmon Declared Fit For Dinner Plates, Nature Biotechnology, January 2016, 7-9.
 
Discussion Six: DNA and the Law
   
1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
   
2. Heather Murphy, Cousin's DNA and Family Trees to Crack Cold Cases, The New York Times, June 27, 2018.
   
3. Jamie Ducharme, Gentic Databases Could Identify Millions of Americans, Time Magazine, October 12, 2018.
 
Discussion Seven: How to Mark Your Genes
   
1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
   
2. Kevin A. Strauss, Genomics for the People, Scientific American, December 2015, 313(6), 66-73.
   
3. Bonnie Rochman, Should Babies Be Sequenced? Scientific American, March 2017, 316: 72-75.
 
Discussion Eight: Human Gene Therapy - The Beginning
   
1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
   
2. Rick Lewis, Gene Therapy's Second Act, Scientific American, March 1, 2014, 310(3).
 
Discussion Nine: Human Gene Therapy - Twenty-First Century Applications
   
1. Leonard Petrucelli & Aaron D. Gitler, Unlocking The Mystery of ALS, Scientific American, June, 2017.
   
2. Lydia Denworth, Finally Making Sense, Scientific American, March, 2020.
   
3. Carrie Arnold, Treatment for ALS Poised to Move Ahead, Nature, February 26, 2020.
 
Discussion Ten: The CRISPR Revolution
   
1. Michael Specter, DNA Revolution, National Geographic Magzine, August 2016, 31-55.
   
2. Carolyn Y. Johnson, Chinese Scientist's Claim of Gene-edited Babies Creates Uproar, The Washington Post, November 26, 2018.
   
3. Ariana E. Cha This Fertility Doctor is Pushing the Boundaries of Human Reproduction with Little Regulation, The Washington Post, May 14, 2018.