Selected Publications
2013 Veldman MB, Zhao C, Gomez GA, Lindgren AG, Huang H, Yang H, Yao S, Martin BL, Kimelman D, Lin S. (2013) Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor etv2. PLoS Biol. 11(6):e1001590.

Ren G, Li S, Zhong H, Lin S. (2013) Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. J Biol Chem. 288(31):22451-9.

Zhao Y, Lin S. (2013) Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Arterioscler Thromb Vasc Biol. 33(6):1280-6.

Zu Y, Tong X, Wang Z, Liu D, Pan R, Li Z, Hu Y, Luo Z, Huang P, Wu Q, Zhu Z, Zhang B, Lin S. (2013) TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat Methods. 10(4):329-31.

Varshney GK, Lu J, Gildea DE, Huang H, Pei W, Yang Z, Huang SC, Schoenfeld D, Pho NH, Casero D, Hirase T, Mosbrook-Davis D, Zhang S, Jao LE, Zhang B, Woods IG, Zimmerman S, Schier AF, Wolfsberg TG, Pellegrini M, Burgess SM, Lin S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome Res. 23(4):727-35.

Lin S, Zhao Y, Nel AE, Lin S. (2013) Zebrafish: an in vivo model for nano EHS studies. Small. 9(9-10):1608-18.

Xiao A, Wu Y, Yang Z, Hu Y, Wang W, Zhang Y, Kong L, Gao G, Zhu Z, Lin S, Zhang B. (2013) EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering. Nucleic Acids Res. 41(Database issue):D415-22.

Varshney GK, Huang H, Zhang S, Lu J, Gildea DE, Yang Z, Wolfsberg TG, Lin S, Burgess SM. (2013) The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion. Nucleic Acids Res. 41(Database issue):D861-4.

Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. (2013) Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 9(9-10):1776-85.
2012 Huang H, Lindgren A, Wu X, Liu NA, Lin S. (2012) High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. Cell Rep. 2012 Sep 27;2(3):695-704.

Chen L, Ren X, Liang F, Li S, Zhong H, Lin S. (2012) Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis. Pigment Cell Melanoma Res. 25(4):446-53.

Zhang Y, Morimoto K, Danilova N, Zhang B, Lin S. (2012) Zebrafish models for dyskeratosis congenita reveal critical roles of p53 activation contributing to hematopoietic defects through RNA processing. PLoS One. 7(1):e30188.

Veldman MB, Lin S. (2012) Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast. Circ Res. 110(2):220-9.
2011 Huang P, Xiao A, Zhou M, Zhu Z, Lin S, Zhang B. (2011) Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol. 29(8):699-700.

Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S. (2011) Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor. Proc Natl Acad Sci U S A. 108(20):8414-9.

Tehrani Z, Lin S. (2011) Endocrine pancreas development in zebrafish. Cell Cycle. 10(20):3466-72.

Zhong H, Wang D, Wang N, Rios Y, Huang H, Li S, Wu X, Lin S. (2011) Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity. Cell Res. 21(7):1080-7.

Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE. (2011) Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano. 5(2):1223-35. Epub 2011 Jan 20.

Ríos Y, Melmed S, Lin S, Liu NA. (2011) Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion. PLoS Genet. 7(1):e1001271.

Tehrani Z, Lin S. (2011) Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development. Development. 138(4):631-40.

Danilova N, Sakamoto KM, Lin S. (2011) Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects. Br J Haematol. 152(2):217-28.
2010 Qi F, Song J, Yang H, Gao W, Liu NA, Zhang B, Lin S. (2010) Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish. Hepatology. 52(6):2158-66.

Zhong H, Xin S, Zhao Y, Lu J, Li S, Gong J, Yang Z, Lin S. (2010) Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Mol Biosyst. 6(8):1463-8.

Ren X, Gomez GA, Zhang B, Lin S. (2010) Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 115(26):5338-46.
2009 Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S. (2009) Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem. 284(31):20876-84.

Gomez GA, Veldman MB, Zhao Y, Burgess S, Lin S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994.

Xiang J, Yang H, Che C, Zou H, Yang H, Wei Y, Quan J, Zhang H, Yang Z, Lin S. (2009) Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. PLoS One. 4(2):e4361.

Bukrinsky A, Griffin KJ, Zhao Y, Lin S, Banerjee U. (2009) Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation. Blood. 113(9):2038-46.
2008 Jiang Z, Song J, Qi F, Xiao A, An X, Liu NA, Zhu Z, Zhang B, Lin S. (2008) Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. PLoS Biol. 6(11):e293.

Danilova N, Sakamoto KM, Lin S. (2008) Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. 112(13):5228-37.

Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. (2008) In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 319(2):192-200.

Mei J, Zhang QY, Li Z, Lin S, Gui JF. (2008) C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol. 319(2):273-84.

Wei W, Wen L, Huang P, Zhang Z, Chen Y, Xiao A, Huang H, Zhu Z, Zhang B, Lin S. (2008) Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesis. Cell Res. 18(6):677-85.

Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS and Choi K (2008) ER71 acts downstream of BMP, Notch and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2(5):497-507

Sumanas S, Gomez G, Zhao Y, Park C, Choi K, and Lin S. (2008) Interplay between Etsrp/ER71, scl and alk8 signaling controls endothelial and myeloid cell formation. Blood. 111(9):4500-10.
Yang Z, Jiang H, Zhao F, Shankar D, Sakamoto KM, Zhang MQ, and Lin S. (2007) A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish. BMC Dev Biol. 7(1):97.

Wang D, Jao LE, Zheng N, Dolan K, Ivey J, Zonies S, Wu X, Wu K, Yang H, Meng Q, Zhu Z, Zhang B, Lin S, and Burgess SM. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proc Natl Acad Sci U S A. 104(30):12428-33 (as corresponding author).

Song J, Kim HJ, Gong Z, Liu NA, and Lin S. (2007) Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Dev Biol. 303(2):561-75
2006 Zhong H, Wu X, Huang H, Fan Q, Zhu Z,  and Lin S (2006) Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proc Natl Acad Sci U S A. 103(45):16800-5.

Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, and Lin S. (2006) Mycophenolic acid is a potent inhibitor of angiogenesis. Arterioscler Thromb Vasc Biol. 26(10):2414-6

Yang Z, Jiang H, Chachainasakul T, Gong S, Yang XW, Heintz N, and Lin S. (2006) Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods. 39(3):183

Liu B, Lee KW, Anzo M, Zhang B, Zi X, Tao Y, Shiry L, Pollak M, Lin S, and Cohen P. (2006) Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis. Oncogene. 26(12):1811-9
Zhao Y, Yang Z, Phelan JK, Wheeler DA, Lin S, and McCabe ER. (2006) Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent. Mol Endocrinol. 20(11):2630-40

Wan H, Korzh S, Li Z, Mudumana SP, Korzh V, Jiang YJ, Lin S and Gong Z. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastase A gene promoter. Exp Cell Res. 312(9):1526-39

Kwan TT, Liang R, Verfaillie CM, Ekker SC, Chan LC, Lin S and Leung AYH. (2006) Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene. Exp Hematology. 34(1):27-34.

Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, and Melmed S (2006) Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 20(4):871-80.
Sumanas S. and Lin, S. (2006) Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 4(1):e10.

Kim HJ, Sumanas S, Palencia-Desai S, Dong Y, Chen JN, and Lin S. (2006) Genetic analysis of early endocrine pancreas formation in zebrafish. Mol Endocrinol. 20(1):194-203.

2005 Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S and Ekker EC (2005) Wnt5 Signaling in Vertebrate Pancreas Development. BMC Biology, 3:23.

Sumanas S, Zhang B, Dai R, and Lin S. (2005) 15-Zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation.  Dev Biol. 283(1):85-96.;

Sumanas S, Jorniak T and Lin S, (2005). Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood, 106(2):534-41

Huang H, Zhang B, Hartenstein PA, Chen JN, and Lin S. (2005) NXT2 is required for embryonic heart development in zebrafish. BMC Dev Biol. 5(1):7.
2004 Shafizadeh E, Peterson RT., and Lin S. (2004) Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comp Biochem Physiol C Toxicol Pharmacol. 138(3):245-9.

Penberthy WT, Zhao C, Zhang Y, Jessen JR, Yang Z, Bricaud O, Collazo A, Meng A and Lin S. (2004) Pur alpha and Sp8 as Opposing Regulators of Neural GATA-2 Expression. Dev Biol. 275(1):225-34.

Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. (2004) The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2(8):E237.

Pi W, Yang Z, Ruan L, Yu X, Ling J, Isales C, Conway SJ, Lin S and D Tuan (2004) The LTR enhancer of ERV-9 human endogenous retrovirus is active during oogenesis in transgenic zebrafish and human. Proc. Natl. Acad. Sci. USA. 01(3): 805-10.
2003 Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, and Zon LI. (2003) Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 4(12):1238-46.

Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, and Look AT. (2003) Myc-induced T cell leukemia in transgenic zebrafish. Science. 299:887-90

Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, and Melmed S. (2003) Pituitary Corticotroph Ontogeny and Regulation in Transgenic Zebrafish. Mol Endocrinol. 17(5):959-66

Brownlie A, Hersey C, Oates AC, Paw BH, Falick AM, Witkowska HE, Flint J, Higgs D, Jessen J, Bahary N, Zhu H, Lin S, and Zon L. 2003 Characterization of embryonic globin genes of the zebrafish. Dev Biol. 255:48-61.

Cross LM, Cook MA, Lin S, Chen JN, and Rubinstein AL. (2003) Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol. 23:911-2.
2002 Shafizadeh, E., Paw, BH., Foott, H., Liao,  EC., Barut, BA., Cope, JJ., Zon, LI., and Lin S. (2002) Characterization of zebrafish merlot/chablis as a non-mammalian vertebrate model for severe congenital anemia due to protein 4.1 deficiency. Development. 129:4359-4370

Lee, KY., Huang, H., Ju, BS., Yang Z., and Lin, S. (2002) Cloned zebrafish by nuclear transfer from long-term cultured cells. Nature Biotechnology.
2001 Huang, H, Liu, N, and Lin, S. (2001) Pdx-1 knockdown reduces insulin promoter activity in zebrafish. Genesis. 30:134-6.

Jessen, JR., Jessen, TN., Vogel, SS., and Lin, S. (2001) Concurrent Expression of Recombination Activating Genes 1 and 2 in Zebrafish Olfactory Sensory Neurons. Genesis. 29:156-62.

Yang, Z., Liu, N. and Lin, S. (2001) A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Dev Biol. 231(1):138-148.

Huang, HG., Vogel, SS., Liu, N., Melton, DA., and Lin, S. (2001) Analysis of pancreatic development in living transgenic zebrafish. Mol & Cell. Endocrinology. 177:117-24.
Long, Q., Huang, HG., Shafizadeh, E., Liu, N. and Lin, S (2000) Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nature Cell Biology. 2(8): 549-552.
Jessen, JR., Willett, CE and Lin, S. (1999) Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Nature Genetics. 23(1):15-16.

Meng, A.,  Moore, B.,  Hong, T.,  Yuan BZ and Lin, S. (1999) A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 126(6):1259-1268.

Meng, A. Hong, T., Ong, B., Long, QM. and Lin S. (1999) Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1. Blood. 93(2):500-8.
Wang, H., Long, QM., Marty, S., Sassa, S. and Lin, S. (1998) A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics. 20, 239-243.

Jessen, JR., Meng, AM., McFarlane RJ., Paw, BH., Zon, LI., Smith, G. and Lin, S. (1998) Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA.  95, 5121-5126.
Long, QM., Meng, AM., Wang, H., Jessen, JH., Farrell, MJ. and Lin, S. (1997). GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development. 124, 4105-4111.

Meng, A., Tang, H., Ong, BA., Farrell, MJ and Lin, S. (1997). Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA. 94, 6267-6272.

Lin, S., Gaiano, N., Culp, P., Burns, J., Friedmann, T., Yee, J-K. and N. Hopkins (1994). Integration and germ line transmission of a pseudotyped retroviral vector in zebrafish. Science, 265, 666-668.

Lin S, Yang S, Hopkins N. (1994) lacZ expression in germline transgenic zebrafish can be detected in living embryos. Dev Biol. 161(1):77-83.

Lin, S., Long, W., Chen, J. and N. Hopkins (1992). Production of germ-line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos. Proc. Natl. Acad. Sci. USA. 89, 4519-4523.