Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2003


Professor Bob Goldberg




Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:00 - 5:50 PM
  Discussions: Wed : 2:00 - 3:50 PM
Wed : 4:00 - 5:50 PM
  Location: Life Sciences 2320
 
Class Video
Class Syllabus
 

Class Handouts (These files are very big. It will take a while to open.)

 

Learning Unit 1: The Age of DNA - What is Genetic Engineering?

 

Learning Unit 2: What Are Genes & How Do They Work?

 

Learning Unit 3: How Are Genes Cloned & Engineered: The Nuts & Bolts

 

Learning Unit 4: Turning Cells & Organisms Into Factories

 

Learning Unit 5: Science & the Constitution: Who Owns Our Genes?

 

Learning Unit 6: How is the Human Genome Organized & What Changes Can Occur?

 

Learning Unit 7: Detecting Changes in the Human Genome - Are There Races?

 

Learning Unit 8: Genetics and the Law

 
Articles For Discussion
 
Week One: The Basics of Genetic Engineering
   

Stanley N. Cohen
The Manipulation of Genes.
Scientific American, July, 1975, 233 (1), 24-33.

   
Clifford Grobstein
The Recombinant DNA Debate.
Scientific American, July, 1977, 237 (1) 22-33.
 
Week Two: Using Genes to Make Drugs
   
Walter Gilbert and Lydia Villa-Komaroff
Useful Proteins From Recombinant Bacteria.
Scientific American, April, 1980, 242 (4), 74-94.
   
William A. Haseltine
Discovering New Genes For Medicine.
Scientific American, March, 1997, 276 (3), 92-97.
 
Week Three: Using Animals as Drug Factories
   
William H. Velander, Henryk Lubon, and William N. Drohan
Transgenic Livestock as Drug Factories.

Scientific American, January 1997, 276 (1), 70-74.
   
Ian Wilmot
Cloning For Medicine.
Scientific American, December 1998, 279 (6), 58-63.
 
Week Four: Using Plants as Factories for Drugs and Plastics
   
William H. R. Langridge
Edible Vaccines.
Scientific American, September, 2000, 283 (3), 66-71.
   
Tillman U. Gerngross and Steven C. Slater
How Green Are Green Plastics?
Scientific American, August, 2000, 283 (2), 37-41.
   
 
Week Five: Identifying and Testing for Human Disease Genes
   

Michael J. Welsh and Alan E. Smith
Cystic Fibrosis
Scientific American, December,
1995, 273 (6), 52-59.

   

Ray White and Jean-Marc Lalouel
Chromosome Mapping with DNA Markers.
Scientific American, February, 1988, 258 (2), 40-48.

   
John Rennie
Grading the Gene Tests.
Scientific American , June, 1994, 270 (6), 89-97.
 
Week Six: Using DNA Testing in the Courtroom
   
Peter J. Neufeld and Neville Colman
When Science Takes the Witness Stand.
Scientific American, May, 1990, 262 (5), 46-53.
   
Jerry Adler and John McCormick
The DNA Detectives.
Newsweek, November 16, 1998, pg. 64-71 (public domain).
   
Barbara Murray and Brian Duffy
Jefferson's Secret Life.
U.S. News & World Report, November 9, 1998 (public domain).
 
Week Seven: Embryonic Stem Cells and Human Cloning
   
Roger A. Pedersen
Embryonic Stem Cells For Medicine.
Scientific American, April, 1999, 280 (4), 68-73.
   
Ronald M. Kline
Whose Blood Is It Anyway?
Scientific American, April, 2001, 284 (4), 42-49.
   
Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo.
Scientific American, January, 2002, 286 (1), 44-51.
 
Week Eight: The Promise of Genomics for Medicine
   
Kathryn Brown
The Human Genome Business Today.
Scientific American, July, 2000, 282 (1), 50-55.
   
Ken Howard
The Bioinformatics Gold.
Scientific American, July, 2000, 282 (1), 58-63.
   
Stephen H. Friend and Roland B. Stoughton
The Magic of Microarrays.
Scientific American, February, 2002, 286 (2), 44-53.
   
 
Week Nine: Gene Therapy: Fixing Human Genetic Defects
   
   
Theodore Friedman
Overcoming the Obstacles to Gene Therapy.
Scientific American, June, 1997, 276 (6), 96-101.
   
Steve Mirsky and John Rennie
What Cloning Means for Gene Therapy?
Scientific American, June, 1997, 276 (6), 122-123.
 
Week Ten: Anthrax and Defending Against Bioweapons
   
John T. Young and R. John Collier
Attacking Anthrax.
Scientific American, March, 2002, 286 (3), 48-59.
   
Rocco Casagrande
Technology Against Terror
.
Scientific American, October, 2002, 287 (3), 83-87.
   
Stephen S. Morse
Vigilance Defense.
Scientific American, October, 2002, 287 (3), 88-89.