Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2005


Professor Bob Goldberg

Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:30 - 5:50 PM
  Discussions: Wed : 2:00 - 3:50 PM Teaching Assistant Tomo Kawashima
Wed : 4:00 - 5:50 PM Teaching Assistant Mike Gavino
 Wed : 6:00 - 7:50 PM Teaching Assistant Tiffany Sum
  Location: Life Sciences 2320
 
Class Video
Class Syllabus
 

Class Handouts

 

Lecture Handout 1: The Age of DNA - What is Genetic Engineering?

 

Lecture Handout 2: What Are Genes?

 

Lecture Handout 3: How Do Genes Work?

 

Lecture Handout 4: Nuts & Bolts of Genetic Engineering - The Factor VIII Story

 

Lecture Handout 5: 21st Century Applications of Genetic Engineering

 

Lecture Handout 6 & 7: Science & the Constitution

 

Lecture Handout 8: The Human Genome Project: Detecting & Using Your Gene

 

Lecture Handout 9: Analysis of Sequence Variation in the Human Genome: Are There "Races"?

 

Lecture Handout 10: Genetics & the Law

   
 
Guest Speakers
  Dr. Richard Hamilton, Ph.D.
President and CEO, Ceres, Inc. Thousand Oaks, CA
Title: How to Start a Biotech Company
  Dr. Alan McHugen, D. Phil.
Department of Plant Sciences, University of California, Riverside
Title: GMOs: What's All the Fuss About?
  Officer Harry Klann
Criminologist, Los Angeles Police Department
Title: Using DNA to Catch Criminals
  Dr. Michele Evans, M.D.
Ob/Gyn & Reprodcutive Endocrinologist, Huntington Reproductive Center
Title: In Vitro Fertilization and Genetic Testing
  Dr. Gregory Stock, Ph.D.
Director, Program on Medicine, Technology, and Society, UCLA School of Public Health
Title: Ethical Issues in Human Genetics and Cloning
 
Articles For Discussion
 
Discussion One: The Basics of Genetic Engineering
   

Stanley N. Cohen
The Manipulation of Genes.
Scientific American, July, 1975, 233 (1), 24-33.

   
Clifford Grobstein
The Recombinant DNA Debate.
Scientific American, July, 1977, 237 (1) 22-33.
 
Discussion Two: Using Genes and Genomics to Make Drugs 
   
Walter Gilbert and Lydia Villa-Komaroff
Useful Proteins From Recombinant Bacteria.
Scientific American, April, 1980, 242 (4), 74-94.
   
William A. Haseltine
Discovering New Genes For Medicine.
Scientific American, March, 1997, 276 (3), 92-97.
   
Ken Howard
The Bioinformatics Gold.
Scientific American, July 2000, 282 (1), 58-63.
   
Kathryn Brown
The Human Genome Business Today.
Scientific American, July 2000, 282 (1), 50-55.
 
Discussion Three: Using Animals and Plants as Drug Factories 
   
William H. Velander, Henryk Lubon, and William N. Drohan
Transgenic Livestock as Drug Factories.
Scientific American, January 1997, 276 (1), 70-74.
   
Editorial
Green Gene Revolution..
Scientific American, August, 2004, 291 (2), 8.
   
Stephen A. Goff & John M. Salmeron
Back to the Future of Cereals..
Scientific American, August, 2004, 291 (2), 42-49.
   
William H. R. Langridge
Edible Vaccines..
Scientific American, September, 2000, 283 (3), 66-71.
   
Ian Wilmot
Cloning For Medicine.
Scientific American, December 1998, 279 (6), 58-63.
   
Kathryn Brown
Seeds of Concern..
Scientific American, April, 2001, 284 (4), 52-57.

Discussion Four: Identifying and Testing for Human Disease Genes
   
Ray White and Jean-Marc Lalouel
Chromosome Mappingwith DNA Markers.
Scientific American , February, 1988, 258 (2), 40-48.
   
John Rennie
Grading the Gene Tests.
Scientific American , June, 1994, 270 (6), 89-97.
   
Jeff Wheelwright
Testing Your Future.
Discover, July 2003, 24 (7), 35-40.
   
 
Discussion Five: Using DNA Testing in the Courtroom
   
Peter J. Neufeld and Neville Colman
When Science Takes the Witness Stand.
Scientific American, May, 1990, 262 (5), 46-53.
   
Jerry Adler and John McCormick
The DNA Detectives.
Newsweek, November 16, 1998, pg. 64-71 (public domain)
 
Discussion Six: Embryonic Stem Cells and Cloning for Medicine
 
Roger A. Pedersen
Embryonic Stem Cells For Medicine.
Scientic American, April, 1999, 280 (4), 68-73.
   
Robert Lanza and Nadia Rosenthal
The Stem Cell Challenge.
Scientific American, June 2004, 290 (6), 93-99.
   
Robert P. Lanza, Betsey L. Dresser, & Philip Damiani
Cloning Noah's Ark
Scientific American, November 2000, 283 (5), 84-89.
   
Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo.
Scientific American, January, 2002, 286 (1), 44-51.
   
Robin Marantz Henig
Pandora's Baby
 Scientific American, June, 2003, 266 (6), 63-68. 
 
Discussion Seven: Gene Therapy: Fixing Human Genetic Defects
   
   
   
Theodore Friedman
Overcoming the Obstacles to Gene Therapy.
Scientific American, June, 1997, 276 (6), 96-101.
   
Steve Mirsky and John Rennie
What Cloning Means for Gene Therapy?
Scientific American, June, 1997, 276 (6), 122-123.
 
Discussion Eight: Understanding and Defeating Cancer
   
Webster K. Cavenee and Raymond L. White
The Genetic Basis of Cancer..
Scientific American, March 1995, 273 (3), 72-79.
   
Dirk M. Nettelbeck and David T. Curiel
Tumor-Busting Viruses.
Scientific American, October, 2003, 289 (4), 68-75.
   
Stephen H. Friend and Roland B. Stoughton
The Magic of Microarrays.
Scientific American, February, 2002, 286 (2), 44-53.
   
Michael D. Lemonick and Alice Park
New Hope For Cancer
Time, May 28, 2001, pgs. 63-69.
 
Discussion Nine: Anthrax and Defending Against Bioweapons
   
John T. Young and R. John Collier
Attacking Anthrax.
Scientific American, March, 2002, 286 (3), 48-59.
   
Jeffery K. Taubenberger, Ann H. Reid, and Thomas G. Fanning
Capturing a Killer Flu Virus
Scientific American, January, 2005, 292 (1), 62-71.
   
Rocco Casagrande
Technology Against Terror.
Scientific American, October, 2002, 287 (3), 83-87.