Selected Research Publications

Selected Review Articles

van Loon, A.P., Erofeev, I.S., Goryachev, A.B., and A. Sagasti (2021). Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells. Mol Biol Cell:mbcE21050258. doi: 10.1091/mbc.E21-05-0258. pdf

Inaba, Y., Chauhan, V., van Loon, A.P., Choudhury, L.S., and A. Sagasti (2020). Keratins and Plakin family cytolinker proteins control the length of epithelial microridge protrusions. Elife 9:e58149. doi: 10.7554/eLife.58149. pdf

van Loon, A.P*., Erofeev, I.S*., Maryshev, I.V., Goryachev, A.B#., and A. Sagasti# (2020). Cortical contraction drives the 3D patterning of epithelial cell surfaces. J Cell Biol. 219(3):e201904144. doi: 10.1083/jcb.201904144. pdf

*Co-first authors,  #Co-corresponding authors

Cokus, S.J., De La Torre, M., Medina, E.F., Rasmussen, J.P., Ramirez-Gutierrez, J., Sagasti, A., and F. Wang (2019). Tissue-specific transcriptomes reveal gene expression trajectories in two maturing skin epithelial layers in zebrafish embryos. G3 9:3439–3452. pdf

Jiang, N., Rasmussen, J.P., Clanton, J.A., Rosenberg, M.F., Luedke, K.P., Cronan, M.R., Parker, E.D., Kim, H.-J., Vaughan, J.C., Sagasti, A., and J.Z. Parrish (2019). A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. Elife 8: pii: e42455. pdf

Julien, D.P., Chan, A.W., Barrios, J., Mathiaparanam, J., Douglass, A., Wolman, M. A. and A. Sagasti (2018). Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. Journal of Neurogenetics, Sep 11:1-17. pdf

Rasmussen, J.P., Vo, N-T, and A. Sagasti (2018). Fish scales dictate the pattern of adult skin innervation and vascularization. Developmental Cell 46(3):344-359. pdf

Madigan, C.A., Cambier, C.J., Kelly-Scumpia, KM, Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A.*, Modlin, R.L.*, and L. Ramakrishnan* (2017). A macrophage response to mycobacterium leprae phenolic glycolipid initiates nerve damage in leprosy. Cell 170(5): 973-985. pdf

Vargas, M.E., Yamagashi, Y., Tessier-Lavigne, M. and A. Sagasti (2015). Live imaging of calcium dynamics during axon degeneration reveals two functionally distinct phases of calcium influx. Journal of Neuroscience 35(45):15026-38. pdf

Rasmussen, J.P., Sack, G.S., Martin, S.M. and A. Sagasti (2015). Vertebrate epidermal cells are broad specificity phagocytes that clear sensory axon debris. Journal of Neuroscience 35(2):559-70. pdf

O'Donnell, K.C., Lulla, A., Stahl, M.C., Wheat, N.D., Bronstein, J.M., and A. Sagasti (2014). Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity. Disease Models and Mechanisms 7(5):571-82. pdf

O'Donnell, K.C., Vargas, M.E., and A. Sagasti (2013). WldS and PGC-1α Regulate Mitochondrial Transport and Oxidation State after Axonal Injury. Journal of Neuroscience 33(37):14778-90. pdf

Palanca, A.M.S., Lee, S.L., Yee, L.E., Joe-Wong, C., Trinh, L.A., Hiroyasu, E., Husain, M., Fraser, S.E., Pellegrini, M. and A. Sagasti (2012). New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Developmental Neurobiology, 73(2):152-67. pdf

Villegas, R.,* Martin, S.M.,* O'Donnell, K., Carrillo, S., Sagasti, A.# and M.L. Allende# (2012). Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development 8;7(1):19. pdf

Wang, F., Wolfson, S.N., Gharib, A, and A. Sagasti (2012). LAR Receptor Tyrosine Phosphatases and HSPGs guide peripheral sensory axons to the skin. Current Biology, 22(5):373-82. pdf

O'Brien, G.S., Rieger, S., Wang, F., Smolen, G.A., Gonzalez R.E., Buchanan J., and A. Sagasti (2012). Coordinate development of skin cells and cutaneous sensory axons in zebrafish. Journal of Comparative Neurology, 520(4):816-31. pdf

Rieger, S. and A. Sagasti (2011). Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biology, 9(5):e1000621. pdf

Martin, S.M., O'Brien, G.S., Portera-Cailliau, C., and A. Sagasti (2010). Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning. Development,137(23):3985-94. pdf

O’Brien, G.S., Martin S.M., Sollner, C., Wright, G.J., Becker, C.G., Portera-Cailliau, C. and A. Sagasti (2009). Developmentally Regulated Impediments to Skin Reinnervation by Injured Peripheral Sensory Axon Terminals.  Current Biology, 19(24):2086-90. pdf

O'Brien G.S., Rieger S., Martin S.M., Cavanaugh A.M., Portera-Cailliau C., and A. Sagasti (2009). Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos. JoVE,  24: 10.3791/1129. link

Sagasti, A., Guido, M.R., Raible, D.W., and A.F. Schier (2005). Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors.  Current Biology, 10: 804-814. pdf

Sagasti, A. and J.P. Rasmussen (2019). Teenage mutant zebrafish: scales transform the skin as fish grow into adulthood. Fronteirs for Young Scientists: May 2019. link

Rosa, J.B., and A. Sagasti (2019). Developmental neurobiology: It takes Nrg to separate dendrites. Current Biology 29(9):R327-R329. pdf

Rasmussen, J.P., and A. Sagasti (2016). Learning to swim, again: Axon regeneration in fish. Exp Neurol. pii: S0014-4886(16)30044-9. doi: 10.1016/j.expneurol.2016.02.022 pdf

Julien D.P., and A. Sagasti (2014). Synaptic specificity: when the neighbors are away, sensory axons turn promiscuous. Current Biology 24(24):R1168-70. pdf

Wang F., Julien D.P., and A. Sagasti (2013) Journey to the skin: Somatosensory peripheral axon guidance and morphogenesis. Cell Adhesion and Migration 7(4):388-94. pdf

Rieger, S., Wang, F. and A. Sagasti (2011). Time-lapse imaging of neural development:  Zebrafish lead the way into the fourth dimension. Genesis 49(7):534-45. pdf

Grueber, W.B and A. Sagasti (2010).  Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing. Cold Spring Harb Perspect Biol. 2(9):a001750. pdf

O'Brien, G.S. and A. Sagasti (2009). Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration. Science Signaling 2(69): 30. pdf

Sagasti, A. (2007).  Three ways to make two sides:  genetic models of asymmetric nervous system development. Neuron  55: 345-351. pdf

Adula, K.P., Shorey, M., Chauhan, V., Nassman, K., Chen, S-F., Rolls, M.M., and A. Sagasti (2021). The MAP3Ks DLK and LZK direct diverse responses to axon damage in zebrafish peripheral neurons. bioRXiv preprint. doi: 10.1101/2021.07.03.450951. link

Palanca, A.M.S. and A. Sagasti (2013). Optogenetic activation of zebrafish somatosensory neurons using ChEF-tdTomato. Journal of Visualized Experiments (71):e50184 link

Rosa, J.B., Nassman, K.Y., and A. Sagasti (2021). Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. bioRXiv preprint. doi: 10.1101/2021.12.23.474011. link

Lu, T.Q., van Loon, A.P., and A. Sagasti (2022). How to wrinkle a cell: Emerging mechanisms of microridge morphogenesis. Curr Opin Cell Biol. 2022 May 12;76:102088. pdf