Goldberg Lab
Course Info Course Documents Useful Links Goldberg Lab CCLE Class Website
Course Information
Units: 5
Lectures: Tuesdays & Thursdays
3:30-6:00 PM
Location: Zoom Meeting
Link available via the CCLE
Discussions: Wednesdays (Zoom Meeting)
12-2:00 PM
2-4:00 PM
4-6:00 PM
Office Hours: Fridays (Zoom Meeting)
with Dr. Bob Goldberg
2-4:00 PM
or by appointment
Class Handouts and Powerpoint Presentations
Week 1
03/30/21 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One)
04/01/21 - Film: Race For the Double Helix
Week 2
04/6/21 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two)
04/08/21 - Films: The Gene Engineers; Designing Life; Genetic Information Age
Week 3
04/13/21 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One)
04/15/21 - Film: Extraordinary Measures
Week 4
04/20/21 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two)
04/22/21 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Insulin & Hemophilia Story
Week 5
04/27/21 - Lecture Six Handout (pdf): A Twenty-First Century Genetic Engineering Applications
04/29/21 - Film: Food Evolution
Guest Speaker: Dr. Channapatna Prakash
Week 6
05/04/21 - All-Class Midterm Oral Exam
05/06/21 - Guest Speaker: Harry Klann, Supervising Criminologist, DNA Unit, LAPD, Retired
Week 7
05/11/21 - Lecture Seven Handout (pdf): Age of Genomics: Three Parent Babies, Human Origins, and Race
05/13/21 - Guest Speaker: In Vitro Fertilization and Genetic Testing by Dr. Michele Evans
Week 8
05/18/21 - Lecture Eight Handout (pdf): Human Genetic Engineering
05/20/21 - Guest Speaker: Stem Cell Biology and Ethics by Dr. Pei Yun Lee
Week 9
05/25/21 - Lecture Nine Handout (pdf): Genetic Engingeering & The Law: Regulating Science & GMOs
05/27/21 - Guest Speaker: The Future of Genetic Engineering & Health by Dr. Daisy Robinton
Week 10
06/01/21 - Lecture Ten Handout (pdf): Genetic Engineering & The Law: Patents & Who Owns Your Genes
06/03/21 - All-Class Final Oral Exam
Guest Speakers
Professor in Plant Molecular Genetics, Tuskegee University
Title: Engineering Crops for the Developing World
Supervising Criminologist, DNA Unit, LAPD (Retired)
Title: DNA Forensics & The Law
Reproductive Specialist, Pacific Fertility Center Los Angeles
Title: In Vitro Fertilization & Genetic Testing
UCLA Department of Molecular, Cell, and Developmental Biology
Title: Stem Cells Biology and Ethics
UScientist in Residence, Cambrian Biopharma
Title: The Future of Genetic Engineering & Health
Articles for Discussion
Discussion One: What Do You Think About Genetic Engineering and GMOs?
Discussion Two: Origins of Genetic Engineering - Hybrid DNA Molecules and Controversy
1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June 1992, 233(1), 24-33.
2. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July 1977, 237(1), 22-33.
Discussion Three: Origins of Biotechnology - From Genes to Drugs
1. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April 1980, 242(4), 74-94.
2. Jon Gertner, Unlocking the Covid Code, New York Times Managzine, March 25 2020.
Discussion Four: From Genes to Vaccines
1. James P. Close, Ancient Plagues Shaped the World, Scientific American, November 2020, 323(5), 70-75.
2. Johnathan Corum, & Carl Zimmer, How Moderna's Vaccine Works, New York Times, March 21 2021.
3. Johnathan Corum, & Carl Zimmer, How the Pfizer-BioNTech Vaccine Works, New York Times, March 22 2021.
4. Johnathan Corum, & Carl Zimmer, How the Johnson & Johnson Vaccine Works, New York Times, March 22 2021.
5. Walter Isaacson, The Vaccine Revolution, Time, January 11 2021.
6. Kathleen Hall Jamieson, & Gordon A. Vehar, How to Counter Covid Misinformation, Scientific American, April 2021, 324(4), 44-51.
7. Anthony S. Fauci, The Story Behind Covid-19 Vaccines, Science, April 2021, 372(6538), 109.
Discussion Five: Genetic Engineering Crops & Farm Animals
1. Charles S. Gasser, & Robert T. Fraley, Transgenic Crops, Scientific American, June 1992, 266(6), 62-69.
2. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
3. Carolyn Y. Johnson, Gene Edited Farm Animals Are Coming, The Washington Post, December 17 2018.
4. Emily Waltz, GM Salmon Declared Fit For Dinner Plates, Nature Biotechnology, January 2016, 7-9.
Discussion Six: DNA and the Law
1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May 1990, 262(5), 46-53.
2. Heather Murphy, Cousin's DNA and Family Trees to Crack Cold Cases, The New York Times, June 27 2018.
3. Jamie Ducharme, Gentic Databases Could Identify Millions of Americans, Time Magazine, October 12 2018.
4. Dave Phillips, To Name Unknown Soldiers, Military Mulls Crime-Solving DNA Methods, The New York Times, April 6 2021.
Discussion Seven: How to Mark Your Genes
1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
2. Kevin A. Strauss, Genomics for the People, Scientific American, December 2015, 313(6), 66-73.
3. Bonnie Rochman, Should Babies Be Sequenced? Scientific American, March 2017, 316: 72-75.
Discussion Eight: Human Gene Therapy - The Beginning
1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
2. Rick Lewis, Gene Therapy's Second Act, Scientific American, March 1, 2014, 310(3), 52-57.
Discussion Nine: Human Gene Therapy - Twenty-First Century Applications
1. Leonard Petrucelli & Aaron D. Gitler, Unlocking The Mystery of ALS, Scientific American, June 2017, 316(6), 46-51.
2. Diana Kwon, Genetic Therapies for Brain Diseases, Nature, April 2021, 592(7853), 180-183.
Discussion Ten: The CRISPR Revolution
1. Michael Specter, DNA Revolution, National Geographic Magzine, August 2016, 31-55.
2. Carolyn Y. Johnson, Chinese Scientist's Claim of Gene-edited Babies Creates Uproar, The Washington Post, November 26 2018.
3. Ariana E. Cha This Fertility Doctor is Pushing the Boundaries of Human Reproduction with Little Regulation, The Washington Post, May 14 2018.