Class Overiew or Class Website
Class Overview or Class website
This course is the entry point for Bob Goldberg's Teaching Program and is incorporated into the General Education Curriculum of the UCLA College Honors Collegium. HC70A is designed to provide non-science majors and entering life science students with a foundation in molecular biology and genetics as it applies to genetic engineering, and addresses the social, legal, and ethical issues that arise from emerging new genetic technologies in medicine, agriculture, and law. A major goal of this class is to put genetic engineering into a scientific, historic, and social perspective so that students can make objective decisions about how this technology should be used in the future. HC70A is highly interactive, team-oriented, problem-based, and teaches students how to think critically about experimental science and the societal issues raised by advances in genetic engineering, genomics, and human reproduction. HC70A is organized into four parts: (1) an interactive, media-oriented lecture section that includes hands-on "experiments" and demonstrations (2) an undergraduate seminar that focuses on Scientific American articles and is taught by undergraduate teaching fellows, (3) an all-class film and guest-speaker section that brings real-life societal issues into the classroom, and (4) a weekly class reception that allows students to interact in an informal setting with Bob Goldberg and discuss science, educational issues, what it is like to be a professor, and other topics that arise spontaneously in this more informal setting.
HC70A, which is enabled through NSF support, reaches students from all majors, on all possible career paths. For example, freshmen debate seniors, entering life science students help non-science students, and classics majors exchange ideas with future biochemistry majors. A unique collective exists in which students representing the ideas, views, and backgrounds of a cross section of the UCLA campus come together to learn and discuss issues related to the impact of genetic engineering and genomics on society. During the past 18 years, 719 students took HC70A, representing 25 different majors. Women outnumbered men. More than 50% of the students were non-science students, and 27% were life science students who had declared a major but were just beginning the core curriculum required of all life science students at UCLA. In addition, there was almost an even distribution among first, second, third, and fourth year students (freshmen are represented at slightly lower levels). The pie charts shown on this page summarize the HC70A student population over the past 18 years.
The HC70A discussion section is taught as an undergraduate seminar, and focuses on Scientific American articles, plays, and debates that simulate "real-life" genetic engineering situations. The articles expand on topics covered in lectures and teach students how to read and think about science. These topics include: (1) the origins of genetic engineering, (2) how genetic engineering is used in agriculture, medicine, and the law, (3) gene therapy, (4) bioweapons, (5) use of genetic engineering to treat cancer, and (6) DNA testing, among others. Students are asked to read the articles critically and focus on four general questions: (1) What is the question being addressed by the article? (2) What are the technologies and approaches being discussed? (3) What is the significance of the technology, and how does it apply to real-life situations? (4) What ethical issues arise as a consequence of the new technology? The plays and debates challenge students to apply the scientific knowledge they have learned in simulated "real-life" situations. They include: (1) a court trial using DNA evidence, (2) a debate on using transgenic animals and plants in medicine & agriculture, and (3) potential environmental problems brought about by the use of genetic engineering. A novel aspect of the discussion section is that it is taught by undergraduate teaching fellows who use the Socratic method to maximize interactions in the class. Teaching fellows call on students by name and ask them to discuss and interpret the experimental results presented in the article(s) read each week. The teaching fellows also moderate lively student discussions and debates on the impact of emerging new genetic technologies on society.
The lecture section is fast-paced, media oriented, highly interactive, and makes extensive use of group learning to teach students how to problem solve and think critically about how major scientific discoveries are made. A variety of unique methods and approaches are used to teach students how to think critically about the questions addressed in lecture.
Bringing Science to Life In the Classroom
Students Talk With a Real Former LAPD Forensic Scientist
Students chat with Harry Klann after his presentation. They were able to see how evidence from actual crime scenes is gathered, processed, and eventually used in prosecutions of both contemporary and cold cases. Mr. Klann describes the pros and cons of cutting edge forensic techniques as well as the history of DNA's role in crime scene investigation.
HC70A Students ask guest speaker Harry Klann, retired LAPD Criminalist, after his lecture
Genotyping Students in the Class
A cheek swab is taken from each student during class and each student's DNA is isolated using a commercial DNA kit. PCR reactions are carried out using D1S80 alpha VNTR primers to describe the range of D1S80 allelic diversity in the HC70A class. Students analyze the gel patterns, describe the range of D1S80 alleles, and calculate their own allelic frequencies relative to the whole class. Click on the link to download the protocol and see sample all-class gel results.
Student demonstrating how to prepare a cheek swab for genotyping
Students "Clone" Bacteria
Students carry out a simulated "cloning experiment" and select for bacteria with different antibiotic markers and genotypes. Students streak bacterial strains with different genotypes in class - no antibiotics, one antibiotic, or two antibiotics - and then take the plates home and observe the results. Students write up a "lab report" on their results, construct hypotheses to explain their results, and propose experiments to test their hypotheses.
Student streak bacteria on plates
Students precipitate and spool DNA out of solution in class. Students discuss what the DNA "looks like," what tissue the DNA came from and how it was extracted, and propose hypotheses to explain its viscosity and ability to wind around a rod.
Students extract DNA from the ethanol solution
| HC70A Winter 2012 Mock Trial
Click on the picture to view clip
| Docudrama Play "The Dominic Problem"
Docudramas That Put Students in Situations That Deal With Science and Society
Group Oral Exams
The group oral exams teaches students how to speak in public and think on their feet. Exam questions utilizes an integrative approach that emphasizes experiments, problem-solving, and connections between different subjects. The oral exam consists of groups answering questions as well as challenging other groups with questions. This format fosters student/student exchanges that challenges students to become "their own teachers".
Using Multimedia to Enhance Class Lectures
HC70A makes extensive use of state-of-the art audio-visual equipment and handouts and so that students can listen in class, interact, and participate in discussions, rather than passively receiving information. Videoconferencing software allows other participating campuses to join in as well, and handouts of all notes and figures are scanned, digitized into a PDF-formatted file, and uploaded on the class web site for student use. Click here to view and download class handouts of Winter 2020.
Lectures are digitally streamed on the class web site and can be accessed 24 hours a day. Lectures are recorded by the Bruincast office, and both Dr. Goldberg and the student use microphones to provide good quality audio. Lectures recorded by Bruincast are also streamed via laptop to distance learners at places like Tuskegee University, allowing real-time participation in the course. The Bruincast office produces videos of every class session that are posted on the class website. Lectures are viewable within an hour after the class has ended.
Food Evolution (2017)
In this film, Neil DeGrasse Tyson narrates Scott Kennedy Hamilton's exploration of the controversy surrounding GMOs by examining the the public debate and the scientific consensus regarding the safety of engineered food.
Extraordinary Measures (2010)
Based on a true story, parents go to extreme lengths to develop a treatment for their children suffering from a life-threatening genetic disease.
Nova: The Gene Engineers (1977)
A documentary examining how society and scientists grappled with legal and ethical questions arising from the birth of genetic engineering.
60 Minutes: George Church (2019)
A Harvard geneticist is working to reverse aging, end genetic diseases, and make humans immune to all viruses. Scott Pelley discusses how close these ideas are to becoming reality, and the potential impacts of these breakthroughs with Dr. Church.
60 Minutes: Designing life - What's next for Craig J. Venter (2010)
A profile of one of the foremost scientists working in genetic engineering, Venter's team mapped the human genome and created a synthetic form of life.
History's Harvest: Where Food Comes From (ASPB Education Foundation) (2002)
In this film, Bob Goldberg explores the controversy of genetic engineering by putting the debate in an historical perspective. The film explores the scientific evidence behind the controversy over genetically modified (GM) food, presenting a sweeping view of 10,000 years of agricultural history. Click here to view clips from the film History's Harvest.
Inherit the Wind (1960)
Based on a real-life case in 1925, two great lawyers argue the case for and against a science teacher accused of the crime of teaching evolution.
The Race for the Double Helix (1987)
Watson and Crick race to find the structure of DNA before Linus Pauling, Maurice Wilkins, or Rosalind Franklin can find the key to unlocking the secret.
Nightline: Kerry Mullis & PCR (1994)
A documentary about the inventor of the polymerase chain reaction (PCR).
Futuristic story of a genetically imperfect man and his seemingly unobtainable goal to travel in space.
Nova: Genetic Prophecy
This program shows the potential benefits and explores some of the social, economic, and ethical dilemmas stemming from the human genome project.
Knowledge or Certainty (The Ascent of Man) (1973)
Moral dilemmas confront todays' scientists, from nuclear energy, to the development of weaponry, to human experiments. Jacob Bronowski offers his personal views.
DNA (Educational Broadcasting Corporation and Windfall Films with Funding From HHMI) (2003)
The Lysenko Affair (Nova) (1975)
GENETIC ENGINEERING IN MEDICINE, AGRICULTURE AND LAW - HC70A
A Different Type of Education in the Classroom